向若兰，副教授，硕士研究生导师

个人简介

2006年6月在中国协和医科大学获得博士学位，2006年9月就职于北京大学医学部生理与病理生理学系。在Eur Hearth J、Cell Res、Aging Cell、Oral Dis、Cells及Life Sci等杂志上发表SCI论文七十余篇。

研究方向

糖尿病及并发症相关机制的研究

口腔唾液腺疾病相关机制的研究

代表性文章

1. Yang YL, Xiang ZJ, Yang JH, Wang WJ, Xu ZC, Xiang RL. Association of β-blocker use with survival and pulmonary function in patients with chronic obstructive pulmonary and cardiovascular disease: a systematic review and meta-analysis. European Heart Journal. 2020, 41: 4415-4422.

2. Chen Z, Mao QY, Zhang JY, Wu YX, Shan XF, Geng Y, Fan JY, Cai ZG*, Xiang RL*. Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice. Aging Cell. 2025, 24(5): e14470.

3. Mao QY, Huang Y, Chen Z, Shan XF, Xie S, Wu LL, Xiang RL*, Cai ZG*. Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis. Cells. 2025, 14(17): 1366.

4. Zou YP, Shan XF, Qiu JX, Geng Y, Xie S, Xiang RL*, Cai ZG*. Systematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carcinoma. Scientific Reports. 2025, 15(1): 1573.

5. Zou YP, Shan XF, Qiu JX, Wang LN, Xiang RL*, Cai ZG*. Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and IκB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing. Biomedicine & Pharmacotherapy. 2024, 174: 116468.

6. Mao QY, Chen Z, Xie S, Xiang RL*, Cai ZG*. F-actin/DRP1 axis-mediated mitochondrial fission promotes mitophagy in diabetic submandibular glands. Oral Diseases. 2024, 00: 1-16.

7. Huang Y, Liu HM, Mao QY, Wu LL, Xiang RL*, Yu GY*. Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse. BMC Genomics. 2024, 25: 450.

8. Huang Y, Liu HM, Mao QY, Cong X, Zhang Y, Lee SW, Park K, Wu LL, Xiang RL*, Yu GY*. High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway. Cells. 2021, 10: 3230.

9. Huang Y, Liu HM, Wu LL, Yu GY, Xiang RL. Long non-coding RNA and mRNA profile analysis in the parotid gland of mouse with type 2 diabetes. Life Sciences. 2021, 268: 119009.

10. Mao QY, Xie S, Wu LL, Xiang RL*, Cai ZG*. MicroRNA-mRNA expression profiles and functional network after injection of botulinum toxin type A into submandibular glands. Toxicon. 2021,199:31-40.

基金项目:

承担多项国家自然科学基金项目和北京市自然科学基金项目。

联系方式 :

Office：生理楼

Email: xiangrl@bjmu.edu.cn