孙金鹏
研究员
个人简介：
孙金鹏，研究员，国家杰出青年科学基金及连续资助(药理学，2018, 2024年)， 新基石项目研究员（2023年）
孙金鹏教授长期从事膜受体G蛋白偶联受体（GPCR）的相关研究，系统性地研究了GPCR感知微环境并调控生理功能的机制，解析了GPCR感知酸碱微环境，痒觉、嗅觉、力以及碳碳双键的分子机制，发现了感知听觉和平衡的GPCR受体，发现了识别类固醇激素膜受体亚家族，识别神经酰胺的膜受体，实现了多个重要GPCR内源性配体的鉴定等；还提出了GPCR偏好性的系列工作模型，包括GPCR信号转导的笛子模型和脯氨酸码头分选理论，为发展GPCR偏好性配体奠定了理论基础。目前以通讯作者在Nature（9篇），Science （2篇，封面）, Cell（9篇，1篇封面），Nature Metabolism（2篇）,Cell Metabolism（2篇），Nat Chem Biol（4篇），Cell Research（2篇），PNAS（6篇），Nat Commun（10篇）等SCI收录杂志发表80余篇文章，并在国际和国内学术大会做特邀报告，产生广泛学术影响。曾获新基石研究员项目资助（2023年）、国家杰出青年科学基金（2018年）、谈家桢生命科学创新奖（2022年）、中华医学科技奖-医学科学技术二等奖（2022年）、第三届全国创新争先奖（2023年）等。目前主持科技部重点研发项目、国家自然科学基金重点项目和面上项目、北京市重点项目等多项基金。
研究方向与领域：
主要研究方向：
GPCR微环境药理学
GPCR感知觉药理学
膜受体药理学
领域：
解析了GPCR感知痒觉、嗅觉、听觉以及力等微环境变化的多种编码机制，探索了听觉和平衡觉受体；发现了识别类固醇的膜受体亚家族；开发了系统的配体-受体筛选方法，实现了20多个重要GPCR脱孤，其中发现代谢过程中多个药靶受体的内源性配体，包括胰岛中嗅觉受体OLFR109的胰岛素多肽配体以及GPR120和GPR132的脂肪酸配体等，为代谢性疾病的治疗提供了干预策略。系统揭示了GPCR功能多样性的机制，创新性地提出了GPCR磷酸化编码的“笛子模型”、脯氨酸码头分选理论，发现了受体磷酸化编码过程中重要的时序作用，为GPCR的偏向性药物开发奠定了理论基础。
实验室成员：
铁璐 副教授
刘杨 讲师
叶菊香 讲师
贾英丽主管技师
博士后：王佳乐、周淑华、滕飞
学生：丁金辉、蔡葵、芮婧钰、解祎赫、庄婉萍、孙雨楠、刘彦君、姜晓静、刘梓立、周浩宇、付锦程、黄宇琪
4、主要代表作：
Jia-Le Wang, Xue-Ying Sha, Yue Shao, Zi-Hao Zhang, Shen-Ming Huang, Hui Lin, Shi-Yi Gan, Nan Zhang, Xin-Yi Xia, Yu-Nan Sun, Jin-Hui Ding, Rui-Qi Zhao, Jie Cheng, Pan Shang, Jin-Peng Wang, Yan-Jun Liu, Fan Yang, Peng Xiao, Lu-Wen Wang, Dong-Yu Zhao, Yi Tang, Lu Tie, Yang Du, Yong Zhang, Ju-Fang He, and Jin-Peng Sun#. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2026 Jan 22;189(2):640-658.e22. 最后通讯作者。
Xiao-Yan Ge, Jie Cheng, Li-Jun Zhang, Lu-Lu Guo, Rui Xiang, Yan Lu, Shang-Lei Ning, Kai-Yu Wang, Kong-Kai Zhu, Ming-Xin Gao, Yue Li, Yu-Song Zhang, Nai-Kang Rong, Xiang Han, Ming-Hui Zhang, Le Fang, Yun-Fei Xu, Su-Wen Zhao, Qian Li, Fan Yang, Yong Hao#, Ren-Jie Chai#, Xiao Yu#, Ji-Chun Yang#, and Jin-Peng Sun#. Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target. Cell. 2026 Jan 21:S0092-8674(25)01429-1. 最后通讯作者。
Xiang Han, Ming-Hui Zhang, Nai-Kang Rong, Kong-Kai Zhu, Yuan Pei, Xiao-Yan Ge, Qi Liu, Huan Lu, Jing Liu, Li-Jun Zhang, Hong-Qiang Bao, Jia-Hao Pi, Lei Fan, Yu Fu, Xu-Hang Shao, Wen-Qi Yan, Xi-He Gao, Ming-Yue Zhang, Lu-Lu Guo, Yan Lu, Shang-Lei Ning, Hua Zhang, Yun-Fei Xu, Xiao-Ya Feng, Jie Cheng, Ming Xia#, Qian Li#, Xiao Yu#, Fan Yang#, and Jin-Peng Sun#. Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors. Cell. 2026 Jan 21:S0092-8674(25)01431-X. 最后通讯作者。
Wen-Qin Xiao, Yan Zhu, Xin-Jie Tang, Kong-Kai Zhu, Wei-Feng Zhang, Meng-Ting Chen, Kui Cai, San Xu, Zheng Wu, Mei Wang, Jia-Yi Liu, Ling-Long Long, Zi-Xin Tan, Ai-Ke Wu, Song-Qi Zhou, Zhi-Xiang Zhao, Yan Tang, Ying-Xue Huang, Ben Wang, Fang-Fen Liu, Qian Wang, Fan Yang, Dan Jian, Wei Shi, Hong-Fu Xie, Xiang Chen, Lu-Lu Guo#, Zhi-Li Deng#, Jin-Peng Sun#, and Ji Li#, Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema, Cell. 2026. 通讯作者，倒数第二位。
Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu#, Peng Xiao#, Fan Yi#, Ines Liebscher#, and Jin-Peng Sun#. Identification, structure, and agonist design of an androgen membrane receptor. Cell. 2025 Mar 20;188(6):1589-1604.e24. 最后通讯作者，引用2次。
Hui Lin, Chuanshun Ma, Kui Cai, Lulu Guo, Xuemei Wang, Lin Lv, Chao Zhang, Jun Lin, Daolai Zhang, Chuan Ye, Tengwei Wang, Shenming Huang, Jifei Han, Zihao Zhang, Junyan Gao, Mingxiang Zhang, Zhao Pu, Fengyang Li, Yongyuan Guo, Xiaojun Zhou, Chengxue Qin, Fan Yi, Xiao Yu#, Wei Kong#, Changtao Jiang#，Jin-Peng Sun#. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 May;388(6746):eado4188.最后通讯作者。
Siting Zhang, Hui Lin, Jiale Wang, Jingyu Rui, Tengwei Wang, Zeyu Cai, Shenming Huang, Yanxiang Gao, Tianfeng Ma, Rui Fan, Rongbo Dai, Zhiqing Li, Yiting Jia, Qiang Chen, HaoMing He, Jiaai Tan, Shirong Zhu, Rui Gu, Zhigang Dong, Meihong Li, Enmin Xie, Yi Fu, Jingang Zheng#, Changtao Jiang#, Jinpeng Sun# & Wei Kong#. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis. Nature. 2025 May;641(8062):476-485. 共同通讯作者，倒数第二位。引用 1次。
Chunyou Mao, Peng Xiao, Xiao-Na Tao, Jiao Qin, Qing-Tao He, Chao Zhang, Sheng-Chao Guo, Ya-Qin Du, Li-Nan Chen, Dan-Dan Shen, Zhi-Shuai Yang, Han-Qiong Zhang, Shen-Ming Huang, Yong-Hao He, Jie Cheng, Ya-Ni Zhong, Pan Shang, Jun Chen, Dao-Lai Zhang, Qian-Lang Wang, Mei-Xia Liu, Guo-Yu Li, Yongyuan Guo, H. Eric Xu, Chuanxin Wang, Cheng Zhang, Shiqing Feng#, Xiao Yu#, Yan Zhang#, Jin-Peng Sun#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Apr 7;380(6640):eadd6220. 最后通讯作者，封面文章，高被引论文；引用65次。
Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu#, Yan Zhang & Jin-Peng Sun#. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. 2021 Jan;589(7843):620-626. 最后通讯作者，高被引论文（2022），引用111次。
Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu#, Fan Yang#, Qian Li# & Jin-Peng Sun#. Structural basis of amine odorant perception by a mammal olfactory receptor. Nature. 2023 Jun;618(7963):193-200. 最后通讯作者，引用 36次。
Fan Yang, Lulu Guo, Yu Li, Guopeng Wang, Jia Wang, Chao Zhang, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao# & Jin-Peng Sun#. Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec;600(7887):164-169. 最后通讯作者，获Nature Chemical Biology专题评述，引用93次。
Pan Shang, Naikang Rong, Jing-Jing Jiang, Jie Cheng, Ming-Hui Zhang, Dongwei Kang, Lei Qi, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang#, Qian Li#, Zhen-Hua Shao#, Fan Yang#, and Jin-Peng Sun#. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24. 最后通讯作者，引用16次。
Xin Wen, Pan Shang, Haidi Chen, Lulu Guo, Naikang Rong, Xiaoyu Jiang, Xuan Li, Junyan Liu, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi#, Pengju Zhang#, Fan Yang #, Cheng Deng#, and Jin-Peng Sun#. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. Cell. 2025 Feb 6;188(3):653-670.e24. 最后通讯作者，获Mol Cell杂志专题评论，引用3次。
Yu-Qi Ping, Peng Xiao, Fan Yang, Ru-Jia Zhao, Sheng-Chao Guo, Xu Yan, Xiang Wu, Chao Zhang, Yan Lu, Fenghui Zhao, Fulai Zhou, Yue-Tong Xi, Wanchao Yin, Feng-Zhen Liu, Dong-Fang He, Dao-Lai Zhang, Zhong-Liang Zhu, Yi Jiang, Lutao Du, Shi-Qing Feng, Torsten Schöneberg, Ines Liebscher#, H. Eric Xu# & Jin-Peng Sun#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770. 最后通讯作者，高被引论文，Nature配发同期评述，引用68次。
Peng Xiao, Shengchao Guo, Xin Wen, Qing-Tao He, Hui Lin, Shen-Ming Huang, Lu Gou, Chao Zhang, Zhao Yang, Ya-Ni Zhong, Chuan-Cheng Yang, Yu Li, Zheng Gong, Xiao-Na Tao, Zhi-Shuai Yang, Yan Lu, Shao-Long Li, Jun-Yan He, Chuanxin Wang, Lei Zhang#, Liangliang Kong#, Jin-Peng Sun#, Xiao Yu#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature. 2022 Apr;604(7907):771-778. 共同通讯作者，倒数第二位。高被引论文，引用78次。
Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu#, Linong Ji#, Yanli Pang#, Jin-Peng Sun#, and Changtao Jiang#. A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE. Cell. 2025 10.1016/j.cell.2025.05.010. 共同通讯作者，倒数第二。
Zheng Xu, Lulu Guo, Jingjing Yu, Siyuan Shen, Chao Wu, Weifeng Zhang, Chang Zhao, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Shengyong Yang, Fan Yang, Xiaohui Wang, Xiao Yu#, Yunfei Xu#, Jin-Peng Sun#, Wei Yan#, Zhenhua Shao#. Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature. 2023 Dec;624(7992):672-681.共同通讯作者，倒数第三位。Nature配发同期评述，引用26次。
Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C. Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun#, Xin Xie#, Xiao Yu# & Yan Zhang#. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov;587(7834):499-504.共同通讯作者，倒数第4位。引用121次。
Xiaolong Hu, Weizhen Ao, Mingxin Gao, Lijie Wu, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang#, Jinpeng Sun#, Tian Hua#, Zhi-Jie Liu#. Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature. 2024 Jul;631(8020):459-466. 共同通讯作者，倒数第三。引用18次。。
Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M Rosenbaum, Jin-Peng Sun#, Yang Du#, Lei Zhang#, Xiao Yu#, Zhenhua Shao#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 Feb 18;184(4):943-956.e18. 共同通讯作者，倒数第5位。封面文章。引用98次。
Hui Lin, Chuanshun Ma, Xiao Zhuang, Shuo Liu, Dong Liu, Mingxiang Zhang, Yan Lu, Guangjian Zhou, Chao Zhang, Tengwei Wang, Zihao Zhang, Lin Lv, Daolai Zhang, Xiong-Zhong Ruan, Yunfei Xu#, Renjie Chai#, Xiao Yu#, Jin-Peng Sun# ,Bo Chu#. Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. Cell Metabolism. 2024 Nov 5;36(11):2402-2418.e10. 共同通讯作者，倒数第二位置。引用5次，获Cell Metabolism同期专题评论。
Jie Cheng, Zhao Yang, Xiao-Yan Ge, Ming-Xin Gao, Ran Meng, Xin Xu, Yu-Qi Zhang, Rui-Zhe Li, Jing-Yu Lin, Zhao-Mei Tian, Jin Wang, Shang-Lei Ning, Yun-Fei Xu, Fan Yang, Jing-Kai Gu, Jin-Peng Sun#, Xiao Yu#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metabolism. 2022 Feb 1;34(2):240-255. 共同通讯作者，倒数第二位。引用44次。
Ting Zhou, Jie Cheng, Shuo He, Chao Zhang, Ming-Xin Gao, Li-Jun Zhang, Jin-Peng Sun#, Yi Zhu#, Ding Ai#. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. Nature Metabolism. 2024 Aug;6(8):1566-1583. 共同通讯作者，倒数第三。引用3次。
Jia-Le Wang, Xiao-Dong Dou, Jie Cheng, Ming-Xin Gao, Guo-Feng Xu, Wei Ding, Jin-Hui Ding, Yu Li, Si-Han Wang, Zhao-Wei Ji, Xin-Yi Zhao, Tong-Yu Huo, Cai-Fang Zhang, Ya-Meng Liu, Xue-Ying Sha, Jia-Rui Gao, Wen-Hui Zhang, Yong Hao, Cheng Zhang, Jin-Peng Sun#, Ning Jiao#, Xiao Yu#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nature Metabolism. 2023 Oct;5(10):1726-1746. 共同通讯作者，倒数第三。引用14次。
Jin-Peng Sun#, Peng Xiao, Ines Liebscher#. The therapeutic potential of orphan adhesion G-protein-coupled receptors. Nature reviews. Drug discovery, 2026, Advance online publication. 第一兼通讯作者。引用0次。
Zhao Yang, Jun-Yan Wang, Fan Yang, Kong-Kai Zhu, Guo-Peng Wang, Ying Guan, Shang-Lei Ning, Yan Lu, Yu Li, Chao Zhang, Yuan Zheng, Shu-Hua Zhou, Xin-Wen Wang, Ming-Wei Wang, Peng Xiao, Fan Yi, Cheng Zhang, Peng-Ju Zhang, Fei Xu, Bao-Hua Liu, Hua Zhang, Xiao Yu#, Ning Gao#, Jin-Peng Sun#. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nature Chemical Biology. 2024 Apr;20(4):484-492. 最后通讯作者，引用13次。
Hui Lin, Peng Xiao, Rui-Qian Bu, Shengchao Guo, Zhao Yang, Daopeng Yuan, Zhong-Liang Zhu, Chuan-Xin Zhang, Qing-Tao He , Chao Zhang, Yu-Qi Ping, Ru-Jia Zhao, Chuan-Shun Ma, Chang-Hao Liu, Xiao-Ning Zhang, Dan Jiang, Shaohui Huang, Yue-Tong Xi, Dao-Lai Zhang, Chen-Yang Xue, Bai-Sheng Yang, Jian-Yuan Li, Hao-Cheng Lin, Xu-Hui Zeng, Han Zhao, Wen-Ming Xu, Fan Yi#, Zhongmin Liu#, Jin-Peng Sun # and Xiao Yu #. Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. Nature Chemical Biology. 2022 Nov;18(11):1196-1203. 共同通讯作者，倒数第二位。引用22次。
Fan Yang, Peng Xiao, Chang-xiu Qu, Qi Liu, Liu-yang Wang, Zhi-xin Liu, Qing-tao He, Chuan Liu, Jian-ye Xu, Rui-rui Li, Meng-jing Li, Qing Li, Xu-zhen Guo, Zhao-ya Yang, Dong-fang He, Fan Yi, Ke Ruan, Yue-mao Shen, Xiao Yu, Jin-Peng Sun# and Jiangyun Wang#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nature Chemical Biology. 2018 Sep;14(9):876-886. 共同通讯作者，倒数第二位。引用51次。
Yuan Zheng, Dan Jiang, Yan Lu, Chao Zhang, Shen-Ming Huang, Haocheng Lin, Daolai Zhang, Shengchao Guo, Jifei Han, Jun Chen, Yaxuan He, Mingxiang Zhang, Yanhui Gao, Yongyuan Guo, Ran Wei, Ming Xia, Yingying Qin, Zhaoqian Liu, Fan Yang, Shaohua Ge, Fan Yi, Xiao Yu#, Hui Lin#, Peng Xiao#, Jin-Peng Sun# & Shiqing Feng#. Development of an allosteric adhesion GPCR nanobody with therapeutic potential. Nature Chemical Biology. 2025. https://doi.org/10.1038/ s41589-025-01896-2. 共同通讯作者，倒数第二位。
Lulu Guo, Kongkai Zhu, Ya-Ni Zhong, Mingxin Gao, Junyan Liu, Zhimin Qi, Zili Liu, Naikang Rong, Minghui Zhang, Dongfang Li, Qiyue Zhang, Gongming Yang, Xinxin Zhang, Mingyue Zhang, Ning Ding, Yu-qi Ping, Zhao Yang, Peng Xiao, Ming Xia#, Xiao Yu#, Alatan Gaole#, Jin-Peng Sun#, and Fan Yang#. Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement. Molecular Cell. 2025 Apr 17;85(8):1658-1673.e7. 共同通讯作者，倒数第二，引用1次，Molecular Cell配发同期评述。
Chunyou Mao, Ru-Jia Zhao, Ying-Jun Dong, Mingxin Gao, Li-Nan Chen, Chao Zhang, Peng Xiao, Jia Guo, Jiao Qin, Dan-Dan Shen, Su-Yu Ji, Shao-Kun Zang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Jin-Peng Sun#, and Yan Zhang#. Conformational transitions and activation of the adhesion receptor CD97. Molecular Cell. 2024 Feb 1;84(3):570-583.e7. 共同通讯作者，倒数第二位置。引用5次。
Zhao Yang, Shu-Hua Zhou, Qi-Yue Zhang, Zhi-Chen Song, Wen-Wen Liu, Yu Sun, Ming-Wei Wang, Xiao-Long Fu, Kong-Kai Zhu, Ying Guan, Jie-Yu Qi, Xiao-Hui Wang, Yu-Nan Sun, Yan Lu, Yu-Qi Ping, Yue-Tong Xi, Zhen-Xiao Teng, Lei Xu, Peng Xiao, Zhi-Gang Xu, Wei Xiong, Wei Qin, Wei Yang#, Fan Yi#, Ren-Jie Chai#, Xiao Yu#, Jin-Peng Sun#. A force-sensitive adhesion GPCR is required for equilibrioception. Cell Research. 2025 Apr;35(4):243-264. 最后通讯作者，引用2次，获同期Cell Research专题评论。
Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, Jingang Zheng, Chenfeng Mao, Zhiqing Li, Zhixin Liu, Bing Yu, Tuoyi Li, Meili Wang, Chanjuan Xu, Yiwei Zhou, Guizhen Zhao, Yiting Jia, Wei Guo, Xin Jia, Tao Zhang, Li Li, Ziyi Liu, Shengchao Guo, Mingliang Ma, Heng Zhang, Bo Liu, Junbao Du, Wengong Wang, Chaoshu Tang, Pei Gao, Qingbo Xu, Xian Wang, Jianfeng Liu, Jinpeng Sun# and Wei Kong#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Research. 2021 Jul;31(7):773-790. 共同通讯作者，倒数第二位，引用43次。
Hong-Mei Wang, Yun-Fei Xu, Shang-Lei Ning, Du-Xiao Yang, Yi Li, Yu-Jie Du, Fan Yang, Ya Zhang, Nan Liang, Wei Yao, Ling-Li Zhang, Li-Chuan Gu, Cheng-Jiang Gao, Qi Pang, Yu-Xin Chen, Kun-Hong Xiao, Rong Ma, Xiao Yu#, Jin-Peng Sun#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. 2014 Sep;24(9):1067-90. 最后通讯作者，引用75次。
Yufei Chen, Chenfeng Mao, Rui Gu, Rujia Zhao, Weihao Li, Zihan Ma, Yiting Jia, Fang Yu, Jian Luo, Yi Fu, Jinpeng Sun#, Wei Kong#. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circulation Research. 2022 Dec 2;131(12):1037-1054. 共同通讯作者，倒数第二位。
Qingqing Chu, Yujia Li, Jichao Wu, Yanjiao Gao, Xiangyun Guo, Jing Li, Hang Lv, Min Liu, Wei Tang, Peng Zhan, Tao Zhang, Huili Hu, Hong Liu, Jinpeng Sun#, Xiaojie Wang#, Fan Yi#. Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension. Circulation Research. 2024 Sep 13;135(7):708-721. 共同通讯作者，倒数第三位。引用3次。
Lin-Qi Zhang, Chang-Xiao Che, Ya-Qin Du, Lu-lu Han, Jia-le Wang, Chen-Yu Zhang, Shen-Ming Huang, Zhong-Yuan Zheng, Qing-Tao He, Zhao Yang, Long Zhang, Nan Chen, Fan Yang, Ying-Li Jia, Shi-Min Zhao, De-min Zhou, Chu Wang, Xian Wang, Jin-Peng Sun#, Lu Tie#. N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation. Blood. 2025 May 15;145(20):2374-2389. 共同通讯作者，倒数第二位。
Jun-Hong Dong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, Dong-Fang He, Qiao-Xia Hu, Dao-Lai Zhang, Shang-Lei Ning, Chun-Hua Liu, Chuan Wang, Yue Wang, Xiang-Yao Li, Fan Yi, Amy Lin, Alem W. Kahsai, Thomas Joseph Cahill Ⅲ, Zhe-Yu Chen, Xiao Yu, and Jin-Peng Sun#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1-regulated lactate metabolism. Biological Psychiatry. 2017 Apr 15;81(8):654-670. 独立通讯作者，引用42次，封面文章。
Wentao An, Hui Lin, Lijuan Ma, Chao Zhang, Yuan Zheng, Qiuxia Cheng, Chuanshun Ma, Xiang Wu, Zihao Zhang, Yani Zhong, Menghui Wang, Dongfang He, Zhao Yang, Lutao Du, Shiqing Feng, Chuanxin Wang, Fan Yang, Peng Xiao#, Pengju Zhang#, Xiao Yu#, and Jin-Peng Sun#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proceedings of the National Academy of Sciences of the United States of America. 2022 Apr 12;119(15):e2117004119. 最后通讯作者，引用29次。
Shen-Ming Huang, Meng-Yao Xiong, Lei Liu, Jianqiang Mu, Ming-Wei Wang, Ying-Li Jia, Kui Cai, Lu Tie, Chao Zhang, Sheng Cao, Xin Wen, Jia-Le Wang, Sheng-Chao Guo, Yu Li, Chang-Xiu Qu, Qing-Tao He, Bo-Yang Cai, Chenyang Xue, Shiyi Gan, Yihe Xie, Xin Cong, Zhao Yang, Wei Kong, Shuo Li, Zijian Li, Peng Xiao, Fan Yang, Xiao Yu, You-Fei Guan, Xiaoyan Zhang#, Zhongmin Liu#, Bao-Xue Yang#, Yang Du#, Jin-Peng Sun#. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proceedings of the National Academy of Sciences of the United States of America. 2023 Jul 25;120(30):e2216329120. 最后通讯作者，引用9次。
Ming-Wei Wang, Zhao Yang, Xu Chen, Shu-Hua Zhou, Ge-Lin Huang, Jian-Ning Sun, Hui Jiang, Wen-Ming Xu#, Hao-Cheng Lin#, Xiao Yu#, Jin-Peng Sun#. Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov 9;118(45):e2107363118. 最后通讯作者，引用11次。
Changxiu Qu, Ji Young Park, Min Woo Yun, Qing-tao He, Fan Yang, Kiae Kim, Donghee Ham, Rui-rui Li, T. M. Iverson, Vsevolod V. Gurevich, Jin-Peng Sun#, and Ka Young Chung#. Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 14;118(37):e2026491118. 共同通讯作者，倒数第二位。引用36次。
Lijuan Ma, Fan Yang, Xiang Wu, Chunyou Mao, Lulu Guo, Tianshu Miao, Shao-Kun Zang, Xiaoyu Jiang, Dan-Dan Shen, Tianhui Wei, Hengxing Zhou, Qin Wei, Shiyang Li, Qiang Shu, Shiqing Feng, Changtao Jiang, Bo Chu, Lutao Du#, Jin-Peng Sun#, Xiao Yu#, Yan Zhang#, and Pengju Zhang#. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proceedings of the National Academy of Sciences of the United States of America. 2022 Jul 19;119(29):e2117054119. 共同通讯作者，倒数第4位。引用17次。
联系方式:
孙金鹏
北京大学医学部生理与病理生理系
Email: sunjinpeng@bjmu.edu.cn 或 sunjinpengsdu@126.com
电话：01082805639
实验室以培养未来的科学家和科研骨干为目标，欢迎对生物学研究感兴趣的同学报考，也欢迎医学和生物学相关专业研究生或本科生来我们课题组学习和交流！