杨吉春
教授,系副主任
杨吉春，北京大学博雅学者特聘教授，国家杰出青年基金获得者。
国家科技创新2030“四大慢病”总体专家组成员，北京大学医学部学术委员会委员。曾获国家优秀青年基金，及入选教育部“新世纪优秀人才计划”。学系科研副主任，担任北京大学医学部非编码RNA医学中心主任，中国医药教育协会临床抗感染药物评价与管理委员会副主任委员，中国生化学会代谢专业委员会副主任委员，中国病理生理学会内分泌代谢专业委员会副秘书长。曾获北京市自然基金十二五优秀成果奖、北京市前沿学术成果奖、北京大学绿叶生物医药杰出青年学者奖、入选北京大学医学部优秀人才计划，中国生理学会张锡均优秀论文2等奖。近年来主持国家杰出青年基金、国家优秀青年基金，国家自然基金重点项目和面上项目、及北京市重点项目等项目18项、作为子课题负责人及骨干参加国家基金委重大项目、科技部及卫健委项目等7项。
研究领域：2型糖尿病及其心血管病变发生机制。已发表SCI论文100余篇，获国家发明专利授权三项。
所获基金（部分）：
1. JDRF postdoctoral fellowship grant (Grant No: 3-2005-1048). 2005.8 – 2007.7 100,000 dollars PI
2. NSFC general project：Mechanism of PANDER-induced hepatic insulin resistance 2008.1- 20010.12 300,000 PI
3. NSFC general project：The roles of ATP synthase in regulating insulin secretion in pancreatic beta cells. 2009.1 – 20011.12 330,000 PI
4. NSFC major project: Metabolic receptors in the regulation of glucose and lipid metabolism (30890041) 2009.1－2012.12 1,000,000 Participant
5. Distinguished talent funding of MOE (NCET-08-0009) 2009-2011 500,000 PI
6. NSFC general project: PANDER-FOXO1 axis in the pathogenesis of NAFLD （81170791）2012-2015 700,000 PI
7. 973 project “Mechanisms of hyperlipidemia and NAFDL ”(2012CB517504 ) 2012.1-2016.12 700,000 Participant
8. National Natural Science Foundation--Outstanding Youth Foundation（81322011） 2014.1-2016.12 1,000,000 PI
9. NSFC general project：Mechanism of FAM3A in regulating insulin secretion in pancreatic beta cells (81471035) 2015.1-2018.12 800,000 PI
10.NSFC general project：Long nonocoding RNA AAK143693 regulates hepatic glucose and lipid metabolism via the modulation of PI3K-Akt pathway (81670748) 2017.1-2020.12. 700,000 PI
11.NSFC general project：FOXD3 regulates hepatic glucose/lipid metabolism by controlling the expression of ATP synthase (81870551) 2019.1-2022.12. 570,000 PI
12.The National Science Fund for Distinguished Young Scholars（82025008） 2021-2025 4,000,000 PI
13. NSFC Key program FAM3D-meidated crosstalk among multiple tissues in the regulation of glucose and lipid metabolism（82230024） 2023-2027 2,620,000 PI
科学兼职：
Associate editor of Frontiers in Cell and Developmental Biology, reviewer for Metabolism、STTT、Diabetes、Diabetologia、Nat Comm、Journal of Diabetes、Journal of Endocrinology and Nutrition &Metabolism et al
所发论文（*通讯作者）：
1. Yan Han, Xiang Rui, Hou Song, Chi Yujing, Yang Jichun*. Genetics in NAFLD. Metabolism 2023 (invited review)
2. Yuntao Hu, Jing Li, Xin Li, Rui Xiang, Wenjun Liu, Di Wang, Song Hou, Qinghe Zhao, Xiaoxing Yu, Ming Xu, Dong Zhao, Yujing Chi* and Jichun Yang*. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation. Metabolism 2023 Sep;146:155661. doi: 10.1016/j.metabol.2023.155661. Epub 2023 Jul 16.
3. Yan H, Meng Y, Li X, Xiang R, Hou S, Wang J, Wang L, Yu X, Xu M, Chi Y*, Yang J*. FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase. Metabolism 2023 Feb;139:155372.
4. Qiu B, Li S, Li M, Wang S, Mu G, Chen K, Wang M, Zhu WG, Wang W, Wang J, Li Z*, Yang J*, Yang Y*. KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells. Cell Death Dis. 2023 Feb 27;14(2):164.
5. Han Yan, Xin Li, Rui Xiang, Dong Zhao, Yujing Chi, Qinghua Cui, Jichun Yang*. RIMKLA phosphorylates and activates BHMT1 to repress hepatic lipid synthesis and uptake by increasing Hcy elimination. 2023 (Submitted).
6. Liu X, Hou S, Xiang R, Hu C, Chen Z, Li N, Yan H, Yu X, Li X, Chi Y*, Yang J*. Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis. Metabolism 2022, 136:155292.
7. Zhou Y, Yan H, Liu W, Hu C, Zhou Y, Sun R, Tang Y, Zheng C*, Yang J*, Cui Q*. A multi-tissue transcriptomic landscape of female mice in estrus and diestrus provides clues for precision medicine. Frontiers Cell and Developmental Biology 2022 Dec 16;10:983712. doi: 10.3389/fcell.2022.983712.
8. Yang W, Lyu Y, Xiang R, Yang J*. Long non-coding RNAs in the pathogenesis of insulin resistance. Int J Mol Sci. 2022 Dec 16;23(24):16054.
9. Li J, Yan H, Xiang R, Yang W, Ye J, Yin R, Yang J*, Chi Y*. ATP secretion and metabolism in the regulation of pancreatic beta cell functions and hepatic glycolipid metabolism. Front Physiol 2022 Jun 21;13:918042.
10. Yan H, Chen Z, Zhang H, Yang W, Liu X, Meng Y, Xiang R, Wu Z, Ye J, Chi Y*, Yang J. Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells. Exp Clin Endocrinol Diabetes. 2022 Aug;130(8):498-508.
11. Hu C, Shi J, Chi Y, Yang J* and Cui Q*. Y/X-Chromosome Bearing Sperm Shows Elevated Ratio in the Left but not the Right Testes in Healthy Mice. Life 2021 Nov 11;11(11):1219
12. Chen Z, Liu X, Luo Y, Wang J, Meng Y, Sun L, Chang Y, Cui Q, Yang J*. Repurposing doxepin to ameliorate obesity, steatosis and hyperglycemia by activating HNF4a-FAM3A signaling pathway. Diabetes 2020, 69(6):1126-1139. (Highlighted by F1000 opinion)
13. Xiang R, Chen J, Li S, Yan H, Meng Y, Cai J, Cui Q, Yang Y, Xu M, Geng B*, Yang J*. VSMC-specific deletion of FAM3A attenuated AngII-promoted hypertension and cardiovascular hypertrophy. Circ Res 2020;126(12):1746-1759
14. Yang W, Chi Y, Meng Y, Chen Z, Xiang R, Yan H, Yang J*. FAM3A plays crucial roles in controlling insulin expression and secretion in pancreatic beta cells by activating CaM-FOXA2-PDX1 pathway. FASEB J 2020, 34(3):3915-3931.
15. Shi J, Hu C, Zhou Y, Cui C, Yang J*, Cui Q*. MicroRNA Profiling in Paired Left and Right Eyes, Lungs, and Testes of Normal Mice. Mol Ther Nucleic Acids. 2020 Jul 10;21:687-695.
16. Meng Y, Xiang R, Yan H, Zhou Y, Hu Y, Yang J*, Zhou Y*, Cui Q*. J Cell Mol Med. 2020 Jun 11. doi: 10.1111/jcmm.15472. Online ahead of print.PMID: 32529766.
17. Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W. Nat Commun. 2020 Jun 16;11(1):3067. doi: 10.1038/s41467-020-16918-x.
18. Cui A, Fan H, Zhang Y, Zhang Y, Niu D, Liu S, Liu Q, Ma W, Shen Z, Shen L, Liu Y, Zhang H, Xue Y, Cui Y, Wang Q, Xiao X, Fang F, Yang J*, Cui Q*, Chang Y*. Dexamethasone-induced Krüppel-like factor 9 expression promotes 1 hepatic gluconeogenesis and hyperglycemia. J Clin Invest 2019, 129(6):2266-2278. (With editorial comment)
19. Gao Y, Yang W, Jin L, Xue L*, Yang J*, Cui Q* . Profiling and bioinformatics analysis reveal differential microRNA expression of the left and right kidneys in normal mice. FEBS Lett 2019 Oct 23. doi: 10.1002/1873-3468.13644.
20. Chi Y, Wang D, Wang J, Yu W, Yang J*. Long non-coding RNA in the pathogenesis of cancers. 2019, Cells. 2019 Sep 1;8(9). pii: E1015
21. Yang J*, Zhang LJ, Wang F, Hong T*, Liu Z*. Molecular imaging diabetes and diabetic complications beyond targeting pancreatic beta cells. Adv Drug Deliv Rev 2019 Jan 15;139:32-50.
22. Yang W, Feng B, Meng Y, Geng B, Cui Q, Zhang H*, Yang Y* and Yang J*. YY1-HSF1 axis is essential for FAM3C (ILEI)- and TGFb-promoted proliferation and migration of breast cancer cells. J Cell Mol Med 2019 May;23(5):3464-3475.
23. Chi Y, Meng Y, Wang J, Wu Z, Li M, Wang D, Gao F, Geng B, Zhang W, Yang J*. FAM3B (PANDER) functions as a co-activator of FOXO1 to promote gluconeogenesis in hepatocytes. J Cell Mol Med 2019 Mar;23(3):1746-1758.
24. Gao X, Leng Y, Guo Y, Yang J, Cui Q, Geng B, Hu H, Zhou Y. BMJ Open. 2019 Aug 20;9(8):e026110.
25. Fan J, Zheng F, Li S, Cui C, Jiang S, Zhang J, Cai J, Cui Q, Yang J, Tang X, Xu G, Geng B. Br J Pharmacol. 2019 Sep;176(17):3180-3192.
26. Song M, Li N, Yao Y, Wang K, Yang J, Cui Q, Geng B, Chen J, Wang Y, Cheng W, Zhou Y. J Cell Mol Med. 2019 Aug;23(8):4970-4979.
27. Zeng P, Chen J, Meng Y, Zhou Y, Yang J*, Cui Q*. Defining essentiality score of protein-coding genes and long noncoding RNAs. 2018, Front Genet. 2018 Oct 9;9:380.
28. Huang C, Yang W, Wang J, Zhou Y, Geng B, Kararigas G, Yang J*, and Cui Q*. The DrugPattern tool for drug set enrichment analysis reveals beneficial effects of oxLDL on type 2 diabetes. J Genet Genomics. 2018 Jul 20;45(7):389-397
29. Wang J, Yang W, Chen Z, Chen J, Meng Y, Feng B, Sun L, Dou L, Li J, Cui Q*, Yang J*. Long nocoding RNA LncSHGL recruits hnRNPA1 to suppress gluconeogenesis and lipogenesis. Diabetes. 2018, 67(4):581-593. (with comment in the issue)
30. Zhang X, Yang W, Wang J, Guan Y* and Yang J*. FAM3 gene family: a promising therapeutical target for NAFLD and type 2 diabetes. Metabolism. 2018, 81:71-82
31. Yang W, Chen J, Meng Y, Chen Z, Yang J*. Novel targets for treating ischemia reperfusion injury in the liver. Int J Mol Sci. 2018 Apr 26;19(5). pii: E1302. doi: 10.3390/ijms19051302.
32. Cui C, Huang C, Liu K, Xu G, Yang J, Zhou Y, Feng Y, Kararigas G, Geng B, Cui Q. Large-scale in-silico identification of drugs exerting sex-specific effects in the heart. J Transl Med. 2018 Aug 29;16(1):236. doi: 10.1186/s12967-018-1612-6.
33. Cui C, Yang W, Shi J, Zhou Y, Yang J, Cui Q, Zhou Y. Genomics Proteomics Bioinformatics. 2018 Jul 10. pii: S1672-0229(18)30130-X. doi: 10.1016/j.gpb.2018.03.004
34. Zheng F, Han J, Lu H, Cui C, Yang J, Cui Q, Cai J, Zhou Y, Tang C, Xu G, Geng B. Biochim Biophys Acta. 2018 Jul 12. pii: S0925-4439(18)30257-6.
35. Ma W, Chen J, Meng Y, Yang J, Cui Q, Zhou Y. Metformin alters gut microbiota of healthy mice: implication for its potential role in gut microbiota homeostasis. Front Microbiol. 2018 Jun 22;9:1336.
36. Liu H, Yao Y, Wang Y, Ji L, Zhu K, Hu H, Chen J, Yang J, Cui Q, Geng B, Liu Q, Li D, Zhou Y. J Cell Mol Med. 2018 Aug 9. doi: 10.1111/jcmm.13803. [Epub ahead of print]
37. Wang Y, Zhou B, Zhou P, Yao Y, Cui Q, Liu Y, Yang J, Wu S, Zhao X, Zhou Y. J Cell Mol Med. 2018,22(4):2329-2336.
38. Xie ZD, Guo YM, Ren MJ, Yang J, Wang SF, Xu TH, Chen LM, Liu Y. Front Physiol. 2018 Jan 25;9:12. doi: 10.3389/fphys.2018.00012. eCollection 2018.
39. Du C, Lin X, Xu W, Zheng F, Cai J, Yang J, Cui Q, Tang C, Cai J, Xu G, Geng B. Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide. Antioxid Redox Signal. 2018 Jan 17. doi: 10.1089/ars.2017.7195. [Epub ahead of print]
40. Jin L, Lin X, Yang L, Fan X, Wang W, Li S, Li J, Liu X, Bao M, Cui X, Yang J, Cui Q, Geng B, Cai J. AK098656, a Novel Vascular Smooth Muscle Cell-Dominant Long Noncoding RNA, Promotes Hypertension. Hypertension 2018 Feb;71(2):262-272
41. Chen Z, Wang J, Yang W, Meng Y, Chen J, Beng B, Zhou Y, Cui Q, Yang J*. FAM3C activates HSF1 to suppress hepatic gluconeogenesis and ameliorate hyperglycemia of type 1 diabetic mice. Oncotarget 2017;8(62):106038-106049
42. Niu X, Yang J, Yang X. J Inorg Biochem. 2017, S0162-0134(17)30143-5.
43. Yang W, Wang J, Chen Z, Chen J, Meng Y, Chen L, Chang Y, Geng B, Sun L, Dou L, Li J, Guan Y, Cui Q, Yang J*. NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway. Diabetes 2017,66(7):1819-1832.
44. Chen Z, Ding L, Yang W, Wang J, Chen L, Chang Y, Geng B, Cui C, Guan Y and Yang J*. Hepatic activation of the FAM3C-HSF1-CaM pathway attenuates hyperglycemia of obese diabetic mice. Diabetes 2017, 66(5):1185-1197.
45. Chen Z, Wang J, Yang W, Chen J, Meng Y, Geng B, Cui Q*, Yang J*. FAM3A mediates PPARγ's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress. Oncotarget. 2017;8(30):49882-49896.
46. Chi Y, Li J, Li N, Chen Z, Ma L, Peng W, Pan X, Li M, Yu W, He X, Geng B, Cui Q, Liu Y*, Yang J*. FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation of ATP-P2-Akt signaling pathway. Oncotarget. 2017 11;8(28):45862-45873
47. Zheng Y, Liao F, Lin X, Zhen F, Fan J, Cui Q, Yang J, Geng B, Cai J. Antioxid Redox Signal. 2017 Oct 10;27(11):742-753.
48. Guo J, Dou L, Meng X, Chen Z, Yang W, Fang W, Yang C, Huang X, Tang W, Yang J, Li J. Sci Rep. 2017 Jan 5;7:39899. doi: 10.1038/srep39899.
49. Chen Q, Yang X, Zhang H, Kong X, Yao L, Cui X, Zou Y, Fang F, Yang J, Chang Y. Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels. Biochim Biophys Acta. 2017 Jan;1864(1):101-112.
50. Ma W, Zhang L, Zeng P, Huang C, Li J, Geng B, Yang J, Kong W, Zhou X, Cui Q. An analysis of human microbe-disease associations. Brief Bioinform. 2017 Jan;18(1):85-97.
51. Wang J, Ma R, Ma W, Chen J, Yang J*, Xi Y*, Cui Q*. LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations. Nucleic Acids Res. 2016 May 19;44(9):e90
52. Cai J, Shi X, Wang H, Fan J, Feng Y, Lin X, Yang J, Cui Q, Tang C, Xu G, Geng B. Biochim Biophys Acta. 2016;1861(5):419-29.
53. Liao F, Zheng Y, Cai J, Fan J, Wang J, Yang J, Cui Q, Xu G, Tang C, Geng B. Sci Rep. 2015 Nov 16;5:16590. doi: 10.1038/srep16590.
54. Chen Z, Luo Y, Yang W, Ding L, Wang J, Geng B, Cui Q* and Yang J*. Comparison analysis of dysregulated LncRNA profile in plasma and liver of mice after hepatic ischemia/reperfusion injury. PloS One 2015 Jul 29;10(7):e0133462.
55. Liu Y, Yang J and Chen L. Structure and function of SLC4 family HCO3– transporters. Front Physiol. 2015 Dec 1;6:355. eCollection 2015.
56. Wang DK, Liu Y, Myers EJ, Guo YM, Xie ZD, Jiang DZ, Li JM, Yang J, Liu M, Parker MD, Chen LM. Effects of Nt-truncation and coexpressing isolated Nt domain on membrane trafficking of electroneutral Na+/HCO3- cotransporters. Sci Rep. 2015 Jul 20;5:12241. doi: 10.1038/srep12241.
57. Wang C, Chen Z, Li S, Zhang Y, Jia S, Li J, Chi Y, Miao Y, Guan Y, Yang J*. Hepatic overexpression of ATP synthase β subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice. Diabetes. 2014, 63:947-59.
58. Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J*, and Guan Y*. FAM3A activates p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. Hepatology. 2014, 59:1779-1790.
59. Jia S, Chen Z, Li J, Chi Y, Wang J, Li S, Luo Y, Geng B, Wang C, Cui Q, Guan Y and Yang J*. FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury. J Mol Cell Cardiol. 2014, 74:173-182.
60. Li J, Ma W, Zeng P, Wang J, Geng B, Yang J, Cui Q. LncTar: a tool for predicting the RNA targets of lncRNAs. Brief Bioinform. 2015, Sep;16(5):806-12.
61. Wang C, Geng B, Cui Q, Guan Y and Yang J*. Intracellular and extracellular adenosine triphosphate in regulation of insulin secretion in pancreatic beta cells J Diabetes. 2014, 6:113-119.
62. Wei B, Cai L, Sun D, Wang Y, Wang C, Chai X, Xie F, Su M, Ding F, Liu J, Yang J, Guan Y and Liu X. Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Idiopathic Pulmonary Fibrosis Induced by Bleomycin in Mice. Molecules. 2014, 19:4967-85.
63. Li Y, Qiu C, Tu J, Geng B, Yang J, Jiang T and Cui Q. HMDD v2.0: a database for experimentally supported human microRNA and disease associations. Nucleic Acids Research. 2014, 42:D1070-4
64. Xu G, Guan Y and Yang J*. FAM3A is a target gene of peroxisome proliferator activated receptor-gamma. Biochim Biophys Acta. 2013,1830: 4160–4170.
65. Chen Z, Jia S, Li D, Tu J, Geng B, Guan Y, Cui Q and Yang J*. Silencing of long noncoding RNA AK139328 attenuates ischemia-reperfusion injury in mouse livers. 2013 PloS One. November 2013, 8(11): e80817.
66. Yang J and Guan Y. Family with sequence similarity 3 and non-alcoholic fatty liver diseases. J Gastroenterol Hepatol 2013, S1:105-11.
67. Yang J, Kang J and Guan Y. The mechanisms linking adiposopathy to type 2 diabetes. Front Med 2013,7(4):433-44.
68. Li Y, Chen G, Wang D, Li Z, Zhou S, Wen J, Geng B, Yang J and Cui Q. Genome-wide analysis of human microRNA stability. BioMed Res Int 2013;2013:368975. doi: 10.1155/2013/368975. Epub 2013 Sep 28.
69. Li D, Chen G, Yang J, Fan X, Gong Y, Xu G, Cui Q, Geng B. Transcriptome analysis reveals distinct patterns of long noncoding RNAs in heart and plasma of mice with heart failure. PloS One. 2013 Oct 29;8(10):e77938.
70. Geng B, Cai B, Liao F, Zheng Y, Zeng Q, Fan X, Gong Y, Yang J, Cui QH, Tang C, Xu GH. Increase or Decrease Hydrogen Sulfide exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese Mice. PloS One. 2013 Sep 13;8(9):e73892
71. Wu J, Wang C, Li S, Li S, Wang W, Li J, Chi Y, Yang H, Kong X, Zhou Y, Dong C, Wang F, Xu G, Yang J, Gustafsson JÅ, Guan Y. Thyroid hormone-responsive spot 14 protein promotes hepatic lipogenesis, and its expression is regulated by LXRα through an SREBP1c-dependent mechanism. Hepatology. 2013;58:617-28.
72. Wang C, Burkhardt BR, Guan Y and Yang J*. Role of pancreatic derived factor in type 2 diabetes: evidence from pancreatic β cells and liver. Nutr Rev. 2012, 70:100-6.
73. Yang J, Zhou Y, Guan Y. PPARγ as a therapeutic target in diabetic nephropathy and other renal diseases. Curr Opin Nephrol Hypertens. 2012, 21:97-105.
74. Zhou Y, Wang C, Li J, Chi Y, Jia S, Guan Y and Yang J*. Expression of PANDER in the pancreas of diabetic mice. Basic & Clinical Medicine. 2012, 32 (7): 756-760.
75. Li J, Chi Y, Wang C, Wu J, Yang H, Zhang D, Zhu Y, Wang N, Yang J*, Guan Y*. Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway. Hepatology. 2011, 53:1906-16.
76. Zhu S, Xue R, Zhao P, Fan FL, Kong X, Zheng S, Han Q, Zhu Y, Wang N, Yang J*, Guan Y*. Targeted disruption of the prostaglandin E2 E-prostanoid 2 receptor exacerbates vascular neointimal formation in mice. Arterioscler Thromb Vasc Biol. 2011, 31:1739-47
77. Han Q, Zhang X, Xue R, Yang H, Zhou Y, Kong X, Zhao P, Li J, Yang J, Zhu Y, Guan Y. AMP-activated protein kinase potentiates hypertonicity-induced apoptosis by blocking the NF-kappaB/COX-2 survival pathway in renal medullary interstitial cells. J Am Soc Nephrol. 2011, 22:1897-911
78. Zhou Y, Kong X, Zhao P, Yang H, Chen L, Miao J, Zhang X, Yang J, Ding J, Guan Y. Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury. Kidney Int. 2011, 79:1302-11.
79. Zhang D, Yang H, Kong X, Wang K, Mao X, Yan X, Wang Y, Liu S, Zhang X, Li J, Chen L, Wu J, Wei M, Yang J and Guan Y. Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. Am J Physiol：Endo and Meta. 2011, 300:287-95.
80. Wang C, Guan Y and Yang J*. Cytokines in the progression of pancreatic beta cell dysfunction. Int J Endocrinol. 2010;2010:515136. Epub 2010 Nov 14.
81. Robert-Cooperman CE, Carnegie JR, Wilson CG, Yang J, Cook JR, Wu J, Young RA, Wolf BA, Burkhardt BR. Targeted disruption of pancreatic derived factor (PANDER, FAM3B) impairs pancreatic beta cell function. Diabetes. 2010, 59:2209-18.
82. Yang J*, Chi Y, Burkhardt BR, Guan Y and Wolf BA. Leucine metabolism in regulation of insulin secretion from panceatic beta cells. Nutr Rev. 2010, 68: 270-279.
83. Yang J*, Wang C, Li J, Burkhardt BR, Robert-Cooperman CE, Wilson C, Gao Z, Wolf BA*. PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells. FEBS Lett. 2009, 583: 3009-3015.
84. Li J, Zhu S, Zhang Y, Chi YJ, Tang JG, Yang JC*. Human leptin dimerization during refolding is predominantly mediated by Cys146-Cys146 intermolecular disulfide bond. Chin J of Biochem and Mol Biology 2009, 25: 333-338
85. Li J, Zhang DJ, Zhang Y, Huang W, Tang JG and Yang JC*. Tyr61 Aromatic Side Chain is Critical for Spatial Structure Formation of Leptin. Chin J of Biochem and Mol Biology. 2009, 25: 235-241.
86. Zhang H, Wang WP, Guo T, Yang JC, Chen P, Ma KT, Guan YF, Zhou CY. The LIM-Homeodomain Protein ISL1 Activates Insulin Gene Promoter Directly through Synergy with BETA2. J Mol Biol. 2009, 392:566-577.
87. Chen L, Yang G, Zhang X, Wu J, Gu Q, Wei M, Yang J, Zhu Y, Wang N, Guan Y. Induction of MIF expression by oxidized LDL via activation of NF-kB in vascular smooth muscle cells. Atherosclerosis 2009, 207:428-33.
88. Yang J, Zhang D，Li J，Zhang X, Fan F and Guan Y. Role of PPAR-γ in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential. Clin Sci. 2009, 116: 17-26.
89. Yang J, Chen L, Zhang X, Zhou Y, Zhang D, Huo M, and Guan Y. PPARs and female reproduction: Evidence from genetically manipulated mice. PPAR Res. 2008, 2008:723243.
90. Yang J, Wong RK, Park MJ, Wu J, Cook JR, York DA, Deng S, Markmann J, Naji A, Wolf BA and Gao Z. Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreaticβcells. Diabetes. 2006, 55: 193-201.
91. Yang J, Robert CE, Burkhardt BR, Young RA, Wu J, Gao Z and Wolf BA. Mechanisms of glucose-induced secretion of pancreatic derived factor (PANDER or FAM3B) in pancreatic beta cells. Diabetes. 2005, 54：3217-3228.
92. Yang J, Gao Z, Robert CE, Burkhardt BR, Gaweska H, Wagner A, Wu J, Greene SR, Young RA and Wolf BA. Structure-Function Studies of PANDER, an Islet Specific Cytokine Inducing Cell Death of Insulin Secreting beta Cells. Biochemistry. 2005, 44：11342-11352.
93. Yang J, Wong RK, Wang X, Moibi J, Hessner MJ, Greene S, Wu J, Sukumvanich S, Wolf BA and Gao Z. Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta cells. J. Biol. Chem. 2004, 279：53915-53923.
94. Yang J, Liu J, Yang X and Tang J. Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle. Biotechnol Lett. 2002, 24：851-855.
95. Narayan SB, Rakheja D, Pastor JV, Rosenblatt K, Yang J, Wolf BA and Bennett MJ. Over-expression of CLN3P, the Batten disease protein inhibits PANDER-induced apoptosis in neuroblastoma cells：CLN3P is a novel anti-apoptotic protein. Mol Genet and Metab. 2006, 88:178-83.
96. Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko T, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH and Wolf BA. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene. 2006, 369: 134-41.
97. Burkhardt BR, Yang MC, Robert CE, Greene SR, McFAdden KK, Yang J, Wu J, Gao Z, Wolf BA. Biochim Biophys Acta. 2005, 1730：215-25.
98. Cao X, Yang J, Burkhardt B, Gao Z, Wong RK, Greene S, Wu J, and Wolf BA. Effects of over-expression of Pancreatic-Derived Factor (FAM3B) in isolated mouse islets and beta-TC3 cells. Am J Physiol：Endo and Meta. 2005, 289：543-550.
99. Wang XD, Tang JG, Xie XL, Yang JC, Li S, Ji JG and Gu J. A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. J Gene Med. 2005, 7：1235-1245.
100. Wang XD, Liu J, Yang JC, Chen WQ and Tang JG. Mice body weight gain is prevented after naked human leptin cDNA transfer into skeletal muscle by electroporation. J Gene Med. 2003, 5：966-76.
101.李晶 张园 赵明明 杨吉春*. 胰岛特异细胞因子PANDER在糖尿病病理生理过程中的作用. 生理科学进展 2008, 39(4):339-342.
102.李晶 张园 管又飞 杨吉春*. ATP合成下降在β细胞功能障碍中的作用 生 理科学进展 2009, 40(1): 47-50.
103.王春炅 张园 管又飞 杨吉春*. 瘦素在机体糖脂代谢中的调控作用. 中国生物化学与分子生物学报. 2009, 25(10): 896-902.
104.迟毓婧 李晶 管又飞 杨吉春*. PI3K-Akt信号传导通路对糖代谢的调控作用. 中国生物化学与分子生物学报 2010, 26(10):879-885.
105.迟毓婧 李晶 管又飞 杨吉春*. 1型糖尿病基因疗法的回顾与展望. 生理科学进展 2010, 41(1):55－58
106.周艳兰 迟毓婧 管又飞 杨吉春*. 脂肪细胞因子与脂肪细胞发育分化. 中国生物化学与分子生物学报 2011, 27(3):212-217.
107.周艳兰 王春炅 管又飞 杨吉春*. FAM3基因家族的研究进展. 生理科学进展2013,44(2):19-23.
108.王春炅 贾石 陈真真 杨吉春*. PANDER与糖脂代谢. 生理科学进展 2013, 44, 425-428.
109.杨卫利 王君佩 崔庆华 杨吉春*. 非编码RNA与肝脏糖脂代谢. 生理科学进展 2016, 47(3):194-202.
110.王君佩 陈真真 崔庆华 杨吉春*. 长非编码RNA与重大临床疾病. 生理科学进展 2016, 47(4):305-308.
111.陈真真 崔庆华 杨吉春*. PPARγ在器官缺血再灌注损伤中的保护作用及机制. 生理科学进展 2017, 18(1):63-68.
112.王君佩 杨吉春*. 长非编码ＲＮＡ与糖尿病及其并发症. 生理科学进展 2019, 55.
113.ATP-嘌呤信号与心血管疾病 向瑞 闫晗 迟毓婧* 杨吉春* 生理科学进展 2022（in press）
114.同型半胱氨酸代谢与疾病 闫晗 向瑞 杨吉春* 迟毓婧* 生理科学进展 2022（in press）
115.王婉奕 朱森 杨吉春 管又飞. Resistin与肥胖和2型糖尿病 生理科学进展 2009, 40(2): 157-160.
116.霍明 臧会玲 张冬娟 王冰 吴静 张晓燕 陈丽红 李晶 杨吉春 管又飞. ChREBP活性增加在2型糖尿病模型db/db小鼠肝脏脂质过度沉积中的作用. 北京大学学报（医学版）2009, 41(3):307-312.
117.朱森 杨吉春 管又飞. 前列腺素E2受体亚型EP2和EP4的最新研究进展. 临床医学工程. 2009,16(7): 109-111.
118.杨航 杨吉春 管又飞. AMPK在糖脂代谢中的作用 生理科学进展 2009, 40(3):249-252
119.赵攀 杨吉春 管又飞. PPARβ/δ在炎症性疾病中的作用. 中国药理学通报. 2009, 25(9):1124-1127
120.霍明 杨吉春 管又飞. ChREBP在肝细胞糖脂代谢中的作用. 生理科学进展 2009, 40(4): 337-340.
121.张冬娟 杨吉春 管又飞. 蛋白质组学技术在糖尿病肾病研究中的应用. 生理科学进展. 2010, 41(2):129-132.
122.苗一非 康继宏 杨吉春 管又飞. 前列腺素E受体与血压调节. 中国药理学通报 2010, 26(4):424-427
123.杨航 杨吉春 管又飞. 高渗应激对肾髓细胞的影响. 生理科学进展. 2010,41(4):287-290.
124.薛瑞 杨吉春 管又飞. 前列腺素E2(PGE2)对免疫系统的调控作用. 生理科学进展 2011, 42(3):165-168.
125.藏会玲 王春炅 杨吉春 管又飞. PPARγ在糖尿病肾病中的保护作用. 生理科学进展 2010, 41(6):435-438.
126.孔晓牧 杨吉春 管又飞. 主要尿蛋白(MUPs)的研究新进展. 中国生物化学与分子生物学报 2011, 27(3):197-204.
联系方式：
北京大学医学部科技楼
E-mail： yangj@bjmu.edu.cn
Tel： 010-8280-5613;
Fax: 010-8280-1447;