Kong Wei-Professors & Researchers-Department of Physiology&Pathophysiology

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Professors & Researchers

Kong Wei

Professor,doctoral supervisor

PI Introduction:

Professor Kong Wei, doctoral supervisor

Email: kongw@bjmu.edu.cn

Kong Wei, Professor, dean of the School of Basic Medical Science and chair of the Department of Physiology and Pathophysiology.

She received her bachelor's degree from Tongji Medical University in 1995. She received her Doctor's degree in basic medical pathophysiology from Tongji Medical College of Huazhong University of Science and Technology in 2000. She was a postdoctoral fellow at University of Washington and New York University School of Medicine from August 2012 to December 2005.

Chang Jiang Scholar of the Ministry of Education, winner of the National Science Fund for Distinguished Young Scholars, selected member of the "Ten Thousand People Plan", and leader of the Innovation group of the National Science Foundation of China. She has published more than 120 SCI papers in authoritative journals of international Cardiovascular journals such as Nature Cardiovascular Research, Circulation, European Heart Journal, Blood, Circulation Research, etc. She is the executive director of the International Society for Matrix Biology (ISMB) and vice president of Chinese Physiological Society. She led the establishment of the professional committee of "Matrix Biology" of the Chinese Physiological Society and served as the first chairman. She served as associate editor of AJP Cell Physiology and editorial boards of the journals including Circulation Research, Matrix Biology, Cardiovascular Res, J Mol Cell Cardiol, and Current Vascular Pharmacology.

Representative articles:

1. Yang X, Xu C, Yao F, Ding Q, Liu H, Luo C, Wang D, Huang J, Li Z, Shen Y, Yang W, Li Z, Yu F, Fu Y, Wang L, Ma Q, Zhu J, Xu F*, Cong X*, Kong W*. Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection. Eur Heart J. 2023 Apr 7;44(14):1248-1261（with editorial comment）. IF:35.855

2. Ma Z, Mao C, Chen X, Yang S, Qiu Z, Yu B, Jia Y, Wu C, Wang Y, Wang Y, Gu R, Yu F, Yin Y, Wang X, Xu Q, Liu C, Liao Y*, Zheng J*, Fu Y*, Kong W*. Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia. Circulation. 2023 Feb 28;147(9):728-742（with editorial comment）. IF:39.922

3. Chen Y, Mao C*, Gu R, Zhao R, Li W, Ma Z, Jia Y, Yu F, Luo J, Fu Y, Sun J*, Kong W*. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circ Res. 2022 Dec 2;131(12):1037-1054. IF:23.218

4. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W*. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. 2021 Oct 12;144(15):1244-1261. IF:39.922

5. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J*, Kong W*. Cartilage oligomeric matrix protein is an endogenous beta-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. 2021 Jul;31(7):773-790（with editorial comment）. IF:46.351

6. Li Z, Zhao Z, Cai Z, Sun Y, Li L, Yao F, Yang L, Zhou Y, Zhu H, Fu Y, Wang L, Fang W, Chen Y*, Kong W*. Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1352-1369. IF: 10.514

7. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J*, Kong W*. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. 2018 Jan 2;9(1):11. IF:17.694

8. Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y*, Kong W*. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation. 2018 Jul 3;138(1):48-63 (with editorial comment). IF:39.922

9. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W*. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015 Aug 13;126(7):905-14 （with editorial comment）. IF:25.669

10. Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z*, Kong W*. ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. Circulation. 2015 Mar 31;131(13):1191-201（with editorial comment）. IF:39.922

Significant grants received:

2020.1-2024.12 National Natural Science Foundation of China Innovation Group (81921001) : Vascular microenvironment and atherosclerosis related vascular disease
2020.1-2024.12 Key Project of National Natural Science Foundation of China (31930056) : Molecular mechanism of FAM19A5 regulating vascular homeostasis and remodeling
2018.1-2011.12 Key Project of National Natural Science Foundation of China (81730010); The role and mechanism of vascular microcalcification in the occurrence and development of aortic aneurysm/dissection
2016.01-2019.12 Key Research Program of "Regulation Mechanism of Vascular homeostasis and remodeling", National Natural Science Foundation of China (No. 91539203); Matrix microenvironment and phenotypic transformation of vascular smooth muscle cells and vascular remodeling
2013.1-2017.12 Major International Cooperation Project of National Natural Science Foundation of China (81220108004); The role of cartilage oligomeric matrix protein COMP in regulating the differentiation of vascular smooth muscle cells and vascular injury repair

Laboratory Members:

Cong Xin, Associate professor, doctoral supervisor

Email: congxin@bjmu.edu.cn

Research Interests: Regulatory mechanisms of tight junctions between cells

Dr. Cong is an Associate Professor and Doctoral Supervisor, Department of Physiology and Pathophysiology, School of Basic Medicine, Peking University. Dr. Cong got a Bachelor of Medicine degree from Peking University in 2007 and a Doctor of Medicine degree in Pathophysiology from the School of Basic Medicine, Peking University in 2012, and worked as a Post-doctor at the Institute of Neuroscience at Peking University from 2012 to 2014. Dr. Cong has been engaged in research on the role and function of intercellular tight junction proteins in the epithelial and endothelial barriers. Dr. Cong has published 65 SCI papers, of which 22 SCI papers (14 in the past five years) as first or corresponding authors (including co-first or co-corresponding authors), such as European Heart Journal (IF=39.3), International Journal of Oral Science (IF=14.9), Journal of Dental Research (IF=7.6), and Arthritis & Rheumatology (IF=13.3), including one paper published with editorial, one paper selected as cover story, and one paper recommended by F1000. Dr. Cong has also been awarded 6 grants as the principal investigator and participated in one major project of the NSFC project as the key member, and won the Young Elite Scientists Sponsorship Program by CAST, the second prize of the Ministry of Education Science and Technology Progress Award (5/17), and the first prize of the Huaxia Medical Science and Technology Award (5/15). Dr. Cong has received many academic awards such as the first prize for oral presentation of outstanding youth papers at the 2016 International Physiology Congress, the second prize for outstanding papers at the 10th National Congress of the Chinese Society of Pathology and Physiology, the third prize for outstanding youth physiology academic papers at the 12th National Youth Physiology Academic Paper Foundation of the Chinese Society of Physiology, and the first prize for excellent papers at the 2015 National Salivary Gland Disease Academic Symposium. Currently, Dr. Cong is the Vice Chairman of the Teaching Professional Committee of the Chinese Association of Pathophysiology, a member of the Integrated Physiology Professional Committee of the Chinese Association for Physiological Sciences, a member of the 13th Board of Directors of the Beijing Association for Physiological Sciences, and a member of the Gastrointestinal Hormones and Mucosal Barrier Group of the Digestive Disease Branch of the Chinese Medical Association.