ZHOU Jing

1. Personal statement

Dr. ZHOU Jing

Tenured Associate Professor

Investigator

ORCID: 0000-0002-2211-4901

Dr. ZHOU Jing obtained her bachelor’s degree in Biomedical Engineering from Chongqing University, Chongqing, China, in 2001. She received her Ph.D. degree from the College of Bioengineering of Chongqing University. She started her postdoctoral work from October 2006 with Dr. Jin-Qiu Zhou at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. In March 2009, as a postdoctoral scholar she joined in Dr. Jeng-Jiann Chiu’s group at the Division of Medical Engineering Research, National Health Research Institute, in Taiwan. She continued her postdoctoral work at University of California (UC), San Diego, United States, working under Dr. Shu Chien in the Department of Bioengineering and Institute of Engineering and Medicine in December 2009. Afterward, she was appointed as Assistant Project Scientist of UC San Diego in July 2011. She joined the faculty of the Peking University Health Science Center, Bejing, China, in June 2014. Dr. Zhou is the recipient of the 100-Talents Plan of Peking University Award, the National Science Fund for Distinguished Young Scholars and the National Science Fund for Excellent Young Scholars Awards. Her research is supported by the National Natural Science Foundation of China and Beijing Natural Scence Foundation. She teaches undergraduate and graduate courses on physiology.

2. Research interest

 Investigating the mechanisms governing communication between the mechanical microenvironment and cells within blood vessel walls, both within living organisms (in vivo) and in laboratory settings (in vitro), as well as exploring drugs and techniques for potential interventions.

 Uncovering and characterizing previously unknown mechanosensory receptor molecules and their methods of sensing mechanical stimuli.

 Studying the processes that regulate vascular function and homeostasis, as well as exploring the development of vascular diseases such as atherosclerosis and strategies for intervention.

3. Academic Service/Work

 Member of the Specialty Committee of Biomechanics, Chinese Society of Biomedical Engineering

 Committee Member of the Chinese Society of Matrix Biology, Chinese Association for Physiological Sciences

 Standing Committee Member of the Vascular Branch of the Chinese Society for Anatomical Sciences

 Council Member of the Beijing Society of Physiological Science

 Member of the Specialty Committee of Vascular Medicine, Chinese Research Hospital Association

 Council Member of the Branch of Single Molecule Biology, Biophysical Society of China

4. Lab members

 YAO Weijuan, Associate Professor. Dr. Yao received her Ph.D. degree from Peking University Health Science Center in June, 2002, and did her postdoc research in Department of Bioengineering at University of California, San Diego. She returned to Peking University Health Science Center and worked in Department of Physiology and Pathophysiology in Sep., 2008. Dr. Yao’s research focus on the cytoskeleton proteins and their roles in hemorheology, biomechanics and cardiovascular diseases. She has published over 40 SCI papers in journals such as JBC, AJP, J Biomechanics, Frontiers in Immunology, and Cell Mol Life Sci., etc. She received several fundings from National Science Foundation of China. Dr. Yao also serves as a committee member in Biomechanics and Biorheology Council of Biophysics Society of China, and Hemorheology Council of Microcirculation Society of China.

 PANG Wei, Associate Professor. He has been working in Department of Physiology and Pathophysiology, Peking University Health Science Center since August, 2002. Dr. Pang received his Ph.D. degree from Peking University Health Science Center in June, 2009 and as an associate professor in August, 2018. He has published several SCI papers in journals such as Circ Res, BBRC, AJP, PLoS One and CEPP, etc. He received 3 projects supported by the National Natural Science Foundation of China and Beijing Municipal Natural Science Foundation.

Current members

Former members



5. Contact information

ZHOU Jing

PhD, Investigator,

Department of Physiology and Pathophysiology

Peking University Health Science Center

Xueyuan Road 38, Haidian District

Tel: +86-10-82801447

Email: jzhou@bjmu.edu.cn

YAO Wei-Juan

Department of Physiology and Pathophysiology

Peking University Health Science Center

Xueyuan Road 38, Haidian District

Tel: +86-10-82802419

Email: weijuanyao@bjmu.edu.cn

PANG Wei

Department of Physiology and Pathophysiology

Peking University Health Science Center

Xueyuan Road 38, Haidian District

Tel: +86-10-82805613

Email: weipang@bjmu.edu.cn

6. Publications

ZHOU Jing:

Selected Publications:

1. Liu J#, Zhao C#, Xiao X, Li A, Liu Y, Zhao J, Fan L, Liang Z, Pang W, Yao W, Li W*, Zhou J*. Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation. Nat Commun. 14(1):6457. 2023.

2. Liu J#, Wang J#, Liu Y, Xie S, Zhang J, Zhao C, Zhou Y, Pang W, Yao W, Peng Q, Wang X*, Zhou J*. Liquid-liquid phase separation of DDR1 counteracts the Hippo pathway to orchestrate arterial stiffening. Circ Res. 132(1):87-105. 2023.

3. Zhao CR#, Li J#, Jiang ZT#, Zhu JJ, Zhao JN, Yang QR, Yao WJ, Pang W, Li N, Yu M*, Gan Y*, Zhou J*. Disturbed flow-facilitated margination and targeting of nanodisks protect against atherosclerosis. Small. e2204694. 2022.

4. Liu H#, Liu Y#, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J*. Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation. Adv Sci (Weinh). e2203995. 2022.

5. Tang Y, Jia Y, Fan L, Liu H, Zhou Y, Wang M, Liu Y, Zhu J, Pang W*, Zhou J*. MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1. Circ Res. 130(11):e26-e43.2022.

6. Wang J#, Xie S#, Li N, Zhang T, Yao W, Zhao H, Pang W, Han L, Liu J, Zhou J*. Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis. Bioact Mater. 17:406-424. 2022.

7. Zhao CR, Yang FF, Cui QH, Wang D, Zhou YR, Li YS, Zhang YP, Tang RZ, Yao WJ, Wang X, Pang W, Zhao JN, Jiang ZT, Zhu JJ, Chien S*, Zhou J*. Vitexin Inhibits APEX1 to Counteract the Flow-Induced Endothelial Inflammation. Proc Natl Acad Sci U S A. 118(48): e2115158118, 2021.

8. Liu YF#, Zhu JJ#, Tian XY, Liu H, Zhang T, Zhang YP, Xie SA, Zheng M, Kong W, Yao WJ, Pang W, Zhao CR, Tang YJ, Zhou J*. Hypermethylation of Mitochondrial DNA in Vascular Smooth Muscle Cells Impairs Cell Contractility. Cell Death Dis. 11 (1), 35, 2020.

9. Xie SA, Zhang T, Wang J, Zhao F, Zhang YP, Yao WJ, Hur SS, Yeh YT, Pang W, Zheng LS, Fan YB, Kong W, Wang X, Chiu JJ, Zhou J*. Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1. Biomaterials. 155:203-216. 2018

10. Zhu JJ#, Liu YF#, Zhang YP, Zhao CR, Yao WJ, Li YS, Wang KC, Huang TS, Pang W, Wang XF, Wang X, Chien S*, Zhou J*. VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia. Proc Natl Acad Sci U S A. 114(31):8271-8276, 2017.

YAO Wei-Juan：

Selected Publications:

1. Liu XM, Yu P, Xu YJ, Wang Y, Chen J, Tang FZ, Hu ZQ, Zhou J, Liu LN, Qiu W, Ye YN, Jia Y, Yao WJ*, Long JH*, Zeng Z*. Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming. Cell Mol Life Sci. 80(10):283, 2023.

2. Zhao CR#, Yang QR#, Tang RZ#, Wang L, Wang J, Yang FF, Zhao JN, Zhu JJ, Pang W, Li N, Zhang X, Tian XY, Yao WJ*, Zhou J*. DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation. NPJ Regen Med. 8(1):29, 2023.

3. Liu XM#, Xia X#, Xifu Wang, Zhou J, Sung LA, Long JH, Geng XY, Zeng Z*, Yao WJ*. Tropomodulin1 expression increases upon maturation in dendritic cells and promotes their maturation and immune functions. Front Immunol. 11: 587441, 2021.

4. Wang WJ, Xu DW, Zhong LJ, Zhang WX, Kang JH, Zhou J, Ka WB, Sun DG, Xia X, Xie LD*, Yao WJ*. Quantitative proteomics reveals TMOD1-related proteins associated with water balance regulation. PLoS One, 14(7): e0219932, 2019.

5. Hu ZQ, Xue H, Long JH, Wang Y, Jia Y, Qiu W, Zhou J, Wen ZY, Yao WJ*, Zeng Z*. Biophysical Properties and Motility of Human Mature Dendritic Cells Deteriorated by Vascular Endothelial Growth Factor through Cytoskeleton Remodeling. Int J Mol Sci. 17(11). pii: E1756, 2016.