Sun Jinpeng
Professor
1. Personal Profile
Jinpeng Sun, Principal Investigator, National Distinguished Young Scholar and Continuous Funding (Pharmacology, 2018, 2024), New Cornerstone Investigator (2023)
Professor Jinpeng Sun has long been engaged in research on G protein-coupled receptors (GPCRs). He has systematically investigated the mechanisms by which GPCRs sense microenvironments and regulate physiological functions, elucidating the molecular mechanisms underlying GPCR sensing of acidic/alkaline microenvironments, itch, olfaction, mechanical force, and carbon-carbon double bonds. He discovered GPCR receptors for auditory and vestibular sensation, identified a subfamily of membrane receptors recognizing steroid hormones, and identified membrane receptors for ceramide. He has achieved the deorphanization of multiple important endogenous GPCR ligands. He also proposed a series of working models for GPCR bias signaling, including the "Flute Model" of GPCR signal transduction and the "Proline Docking Bifurcation" theory, laying the theoretical foundation for the development of GPCR-biased ligands. To date, he has published over 80 papers as corresponding author in SCI-indexed journals including Nature (9 papers), Science (2 papers, cover story), Cell (9 papers, 1 cover story), Nature Metabolism (2 papers), Cell Metabolism (2 papers), Nature Chemical Biology (4 papers), Cell Research (2 papers), PNAS (6 papers), and Nature Communications (10 papers). He has been invited to deliver keynote speeches at international and domestic academic conferences, generating extensive academic impact. He has received funding from the New Cornerstone Investigator Program (2023), National Distinguished Young Scholar Award (2018), Tan Jiazhen Life Science Innovation Award (2022), Chinese Medical Science and Technology Award—Second Prize in Medical Science and Technology (2022), and the 3rd National Award for Innovation and Excellence (2023). He currently leads multiple grants including National Key R&D Program projects from the Ministry of Science and Technology, key projects and general projects from the National Natural Science Foundation of China, and key projects from Beijing Municipality.
2. Research Directions and Fields
Main Research Directions:
GPCR Microenvironment Pharmacology
GPCR Sensory Pharmacology
Membrane Receptor Pharmacology
Research Fields:
His team has elucidated various coding mechanisms by which GPCRs sense microenvironmental changes such as itch, olfaction, audition, and mechanical force, and has explored auditory and vestibular receptors. They discovered a subfamily of membrane receptors recognizing steroids; developed systematic ligand-receptor screening methods, achieving the deorphanization of over 20 important GPCRs, including the identification of endogenous ligands for multiple drug target receptors in metabolic processes, such as insulin peptide ligands for the olfactory receptor OLFR109 in pancreatic islets and fatty acid ligands for GPR120 and GPR132, providing intervention strategies for metabolic disease treatment. They have systematically revealed the mechanisms underlying GPCR functional diversity, innovatively proposing the "Flute Model" of GPCR phosphorylation encoding and the "Proline Docking Bifurcation" theory, and discovered the important temporal sequence effects in receptor phosphorylation encoding, laying the theoretical foundation for the development of GPCR-biased drugs.
3. Laboratory Members
Lu Tie, Associate Professor
Yang Liu, Lecturer
Juxiang Ye, Lecturer
Yingli Jia, Senior Technician
Postdoctoral Fellows: Jiale Wang, Shuhua Zhou, Fei Teng
Students: Jinhui Ding, Kui Cai, Jingyu Rui, Yihe Xie, Wanping Zhuang, Yunan Sun, Yanjun Liu, Xiaojing Jiang, Zili Liu, Haoyu Zhou, Jincheng Fu, Yuqi Huang
4.Selected Publications (Corresponding Author)
Jia-Le Wang, Xue-Ying Sha, Yue Shao, Zi-Hao Zhang, Shen-Ming Huang, Hui Lin, Shi-Yi Gan, Nan Zhang, Xin-Yi Xia, Yu-Nan Sun, Jin-Hui Ding, Rui-Qi Zhao, Jie Cheng, Pan Shang, Jin-Peng Wang, Yan-Jun Liu, Fan Yang, Peng Xiao, Lu-Wen Wang, Dong-Yu Zhao, Yi Tang, Lu Tie, Yang Du, Yong Zhang, Ju-Fang He, and Jin-Peng Sun#. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2026 Jan 22;189(2):640-658.e22. Senior Corresponding Author.
Xiao-Yan Ge, Jie Cheng, Li-Jun Zhang, Lu-Lu Guo, Rui Xiang, Yan Lu, Shang-Lei Ning, Kai-Yu Wang, Kong-Kai Zhu, Ming-Xin Gao, Yue Li, Yu-Song Zhang, Nai-Kang Rong, Xiang Han, Ming-Hui Zhang, Le Fang, Yun-Fei Xu, Su-Wen Zhao, Qian Li, Fan Yang, Yong Hao#, Ren-Jie Chai#, Xiao Yu#, Ji-Chun Yang#, and Jin-Peng Sun#. Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target. Cell. 2026 Jan 21:S0092-8674(25)01429-1. Senior Corresponding Author.
Xiang Han, Ming-Hui Zhang, Nai-Kang Rong, Kong-Kai Zhu, Yuan Pei, Xiao-Yan Ge, Qi Liu, Huan Lu, Jing Liu, Li-Jun Zhang, Hong-Qiang Bao, Jia-Hao Pi, Lei Fan, Yu Fu, Xu-Hang Shao, Wen-Qi Yan, Xi-He Gao, Ming-Yue Zhang, Lu-Lu Guo, Yan Lu, Shang-Lei Ning, Hua Zhang, Yun-Fei Xu, Xiao-Ya Feng, Jie Cheng, Ming Xia#, Qian Li#, Xiao Yu#, Fan Yang#, and Jin-Peng Sun#. Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors. Cell. 2026 Jan 21:S0092-8674(25)01431-X. Senior Corresponding Author.
Wen-Qin Xiao, Yan Zhu, Xin-Jie Tang, Kong-Kai Zhu, Wei-Feng Zhang, Meng-Ting Chen, Kui Cai, San Xu, Zheng Wu, Mei Wang, Jia-Yi Liu, Ling-Long Long, Zi-Xin Tan, Ai-Ke Wu, Song-Qi Zhou, Zhi-Xiang Zhao, Yan Tang, Ying-Xue Huang, Ben Wang, Fang-Fen Liu, Qian Wang, Fan Yang, Dan Jian, Wei Shi, Hong-Fu Xie, Xiang Chen, Lu-Lu Guo#, Zhi-Li Deng#, Jin-Peng Sun#, and Ji Li#, Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema, Cell. 2026. Co-Corresponding Author，Second to Last.
Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu#, Peng Xiao#, Fan Yi#, Ines Liebscher#, and Jin-Peng Sun#. Identification, structure, and agonist design of an androgen membrane receptor. Cell. 2025 Mar 20;188(6):1589-1604.e24. Senior Corresponding Author，Citations:2.
Hui Lin, Chuanshun Ma, Kui Cai, Lulu Guo, Xuemei Wang, Lin Lv, Chao Zhang, Jun Lin, Daolai Zhang, Chuan Ye, Tengwei Wang, Shenming Huang, Jifei Han, Zihao Zhang, Junyan Gao, Mingxiang Zhang, Zhao Pu, Fengyang Li, Yongyuan Guo, Xiaojun Zhou, Chengxue Qin, Fan Yi, Xiao Yu#, Wei Kong#, Changtao Jiang#，Jin-Peng Sun#. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 May;388(6746):eado4188.Senior Corresponding Author.
Siting Zhang, Hui Lin, Jiale Wang, Jingyu Rui, Tengwei Wang, Zeyu Cai, Shenming Huang, Yanxiang Gao, Tianfeng Ma, Rui Fan, Rongbo Dai, Zhiqing Li, Yiting Jia, Qiang Chen, HaoMing He, Jiaai Tan, Shirong Zhu, Rui Gu, Zhigang Dong, Meihong Li, Enmin Xie, Yi Fu, Jingang Zheng#, Changtao Jiang#, Jinpeng Sun# & Wei Kong#. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis. Nature. 2025 May;641(8062):476-485. Co-Corresponding Author，Second to Last, Citations: 1.
Chunyou Mao, Peng Xiao, Xiao-Na Tao, Jiao Qin, Qing-Tao He, Chao Zhang, Sheng-Chao Guo, Ya-Qin Du, Li-Nan Chen, Dan-Dan Shen, Zhi-Shuai Yang, Han-Qiong Zhang, Shen-Ming Huang, Yong-Hao He, Jie Cheng, Ya-Ni Zhong, Pan Shang, Jun Chen, Dao-Lai Zhang, Qian-Lang Wang, Mei-Xia Liu, Guo-Yu Li, Yongyuan Guo, H. Eric Xu, Chuanxin Wang, Cheng Zhang, Shiqing Feng#, Xiao Yu#, Yan Zhang#, Jin-Peng Sun#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Apr 7;380(6640):eadd6220. Senior Corresponding Author，Cover Article，Highly Cited Paper；Citations:65.
Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu#, Yan Zhang & Jin-Peng Sun#. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. 2021 Jan;589(7843):620-626. Senior Corresponding Author，Highly Cited Paper（2022），Citations:111.
Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu#, Fan Yang#, Qian Li# & Jin-Peng Sun#. Structural basis of amine odorant perception by a mammal olfactory receptor. Nature. 2023 Jun;618(7963):193-200. Senior Corresponding Author，Citations: 36.
Fan Yang, Lulu Guo, Yu Li, Guopeng Wang, Jia Wang, Chao Zhang, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao# & Jin-Peng Sun#. Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec;600(7887):164-169. Senior Corresponding Author，Featured review in Nature Chemical Biology，Citations:93.
Pan Shang, Naikang Rong, Jing-Jing Jiang, Jie Cheng, Ming-Hui Zhang, Dongwei Kang, Lei Qi, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang#, Qian Li#, Zhen-Hua Shao#, Fan Yang#, and Jin-Peng Sun#. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24. Senior Corresponding Author，Citations:16.
Xin Wen, Pan Shang, Haidi Chen, Lulu Guo, Naikang Rong, Xiaoyu Jiang, Xuan Li, Junyan Liu, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi#, Pengju Zhang#, Fan Yang #, Cheng Deng#, and Jin-Peng Sun#. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. Cell. 2025 Feb 6;188(3):653-670.e24. Senior Corresponding Author，Featured review in Molecular Cell，Citations:3.
Yu-Qi Ping, Peng Xiao, Fan Yang, Ru-Jia Zhao, Sheng-Chao Guo, Xu Yan, Xiang Wu, Chao Zhang, Yan Lu, Fenghui Zhao, Fulai Zhou, Yue-Tong Xi, Wanchao Yin, Feng-Zhen Liu, Dong-Fang He, Dao-Lai Zhang, Zhong-Liang Zhu, Yi Jiang, Lutao Du, Shi-Qing Feng, Torsten Schöneberg, Ines Liebscher#, H. Eric Xu# & Jin-Peng Sun#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770. Senior Corresponding Author，Highly Cited Paper, with an accompanying commentary in Nature，Citations:68.
Peng Xiao, Shengchao Guo, Xin Wen, Qing-Tao He, Hui Lin, Shen-Ming Huang, Lu Gou, Chao Zhang, Zhao Yang, Ya-Ni Zhong, Chuan-Cheng Yang, Yu Li, Zheng Gong, Xiao-Na Tao, Zhi-Shuai Yang, Yan Lu, Shao-Long Li, Jun-Yan He, Chuanxin Wang, Lei Zhang#, Liangliang Kong#, Jin-Peng Sun#, Xiao Yu#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature. 2022 Apr;604(7907):771-778. Co-Corresponding Author，Second to Last, Highly Cited Paper，Citations:78.
Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu#, Linong Ji#, Yanli Pang#, Jin-Peng Sun#, and Changtao Jiang#. A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE. Cell. 2025 10.1016/j.cell.2025.05.010. Co-Corresponding Author，Second to Last.
Zheng Xu, Lulu Guo, Jingjing Yu, Siyuan Shen, Chao Wu, Weifeng Zhang, Chang Zhao, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Shengyong Yang, Fan Yang, Xiaohui Wang, Xiao Yu#, Yunfei Xu#, Jin-Peng Sun#, Wei Yan#, Zhenhua Shao#. Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature. 2023 Dec;624(7992):672-681.Co-Corresponding Author，Third to Last, with an accompanying commentary in the same issue of Nature，Citations:26.
Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C. Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun#, Xin Xie#, Xiao Yu# & Yan Zhang#. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov;587(7834):499-504.Co-Corresponding Author，fourth to last, Citations:121.
Xiaolong Hu, Weizhen Ao, Mingxin Gao, Lijie Wu, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang#, Jinpeng Sun#, Tian Hua#, Zhi-Jie Liu#. Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature. 2024 Jul;631(8020):459-466. Co-Corresponding Author，Third to Last, Citations:18.
Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M Rosenbaum, Jin-Peng Sun#, Yang Du#, Lei Zhang#, Xiao Yu#, Zhenhua Shao#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 Feb 18;184(4):943-956.e18. Co-Corresponding Author，fifth to last, Cover Article, Citations:98.
Hui Lin, Chuanshun Ma, Xiao Zhuang, Shuo Liu, Dong Liu, Mingxiang Zhang, Yan Lu, Guangjian Zhou, Chao Zhang, Tengwei Wang, Zihao Zhang, Lin Lv, Daolai Zhang, Xiong-Zhong Ruan, Yunfei Xu#, Renjie Chai#, Xiao Yu#, Jin-Peng Sun# ,Bo Chu#. Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. Cell Metabolism. 2024 Nov 5;36(11):2402-2418.e10. Co-Corresponding Author，Second to Last，Citations:5，Featured commentary in the same issue of Cell Metabolism.
Jie Cheng, Zhao Yang, Xiao-Yan Ge, Ming-Xin Gao, Ran Meng, Xin Xu, Yu-Qi Zhang, Rui-Zhe Li, Jing-Yu Lin, Zhao-Mei Tian, Jin Wang, Shang-Lei Ning, Yun-Fei Xu, Fan Yang, Jing-Kai Gu, Jin-Peng Sun#, Xiao Yu#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metabolism. 2022 Feb 1;34(2):240-255. Co-Corresponding Author，Second to Last, Citations:44.
Ting Zhou, Jie Cheng, Shuo He, Chao Zhang, Ming-Xin Gao, Li-Jun Zhang, Jin-Peng Sun#, Yi Zhu#, Ding Ai#. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. Nature Metabolism. 2024 Aug;6(8):1566-1583. Co-Corresponding Author，Third to Last，Citations:3.
Jia-Le Wang, Xiao-Dong Dou, Jie Cheng, Ming-Xin Gao, Guo-Feng Xu, Wei Ding, Jin-Hui Ding, Yu Li, Si-Han Wang, Zhao-Wei Ji, Xin-Yi Zhao, Tong-Yu Huo, Cai-Fang Zhang, Ya-Meng Liu, Xue-Ying Sha, Jia-Rui Gao, Wen-Hui Zhang, Yong Hao, Cheng Zhang, Jin-Peng Sun#, Ning Jiao#, Xiao Yu#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nature Metabolism. 2023 Oct;5(10):1726-1746. Co-Corresponding Author，Third to Last，Citations:14.
Jin-Peng Sun#, Peng Xiao, Ines Liebscher#. The therapeutic potential of orphan adhesion G-protein-coupled receptors. Nature reviews. Drug discovery, 2026, Advance online publication. First & Co-Corresponding Author, Citations:0.
Zhao Yang, Jun-Yan Wang, Fan Yang, Kong-Kai Zhu, Guo-Peng Wang, Ying Guan, Shang-Lei Ning, Yan Lu, Yu Li, Chao Zhang, Yuan Zheng, Shu-Hua Zhou, Xin-Wen Wang, Ming-Wei Wang, Peng Xiao, Fan Yi, Cheng Zhang, Peng-Ju Zhang, Fei Xu, Bao-Hua Liu, Hua Zhang, Xiao Yu#, Ning Gao#, Jin-Peng Sun#. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nature Chemical Biology. 2024 Apr;20(4):484-492. Senior Corresponding Author，Citations:13.
Hui Lin, Peng Xiao, Rui-Qian Bu, Shengchao Guo, Zhao Yang, Daopeng Yuan, Zhong-Liang Zhu, Chuan-Xin Zhang, Qing-Tao He , Chao Zhang, Yu-Qi Ping, Ru-Jia Zhao, Chuan-Shun Ma, Chang-Hao Liu, Xiao-Ning Zhang, Dan Jiang, Shaohui Huang, Yue-Tong Xi, Dao-Lai Zhang, Chen-Yang Xue, Bai-Sheng Yang, Jian-Yuan Li, Hao-Cheng Lin, Xu-Hui Zeng, Han Zhao, Wen-Ming Xu, Fan Yi#, Zhongmin Liu#, Jin-Peng Sun # and Xiao Yu #. Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. Nature Chemical Biology. 2022 Nov;18(11):1196-1203. Co-Corresponding Author，Second to Last，Citations:22.
Fan Yang, Peng Xiao, Chang-xiu Qu, Qi Liu, Liu-yang Wang, Zhi-xin Liu, Qing-tao He, Chuan Liu, Jian-ye Xu, Rui-rui Li, Meng-jing Li, Qing Li, Xu-zhen Guo, Zhao-ya Yang, Dong-fang He, Fan Yi, Ke Ruan, Yue-mao Shen, Xiao Yu, Jin-Peng Sun# and Jiangyun Wang#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nature Chemical Biology. 2018 Sep;14(9):876-886. Co-Corresponding Author，Second to Last,Citations:51.
Yuan Zheng, Dan Jiang, Yan Lu, Chao Zhang, Shen-Ming Huang, Haocheng Lin, Daolai Zhang, Shengchao Guo, Jifei Han, Jun Chen, Yaxuan He, Mingxiang Zhang, Yanhui Gao, Yongyuan Guo, Ran Wei, Ming Xia, Yingying Qin, Zhaoqian Liu, Fan Yang, Shaohua Ge, Fan Yi, Xiao Yu#, Hui Lin#, Peng Xiao#, Jin-Peng Sun# & Shiqing Feng#. Development of an allosteric adhesion GPCR nanobody with therapeutic potential. Nature Chemical Biology. 2025. https://doi.org/10.1038/ s41589-025-01896-2. Co-Corresponding Author，Second to Last.
Lulu Guo, Kongkai Zhu, Ya-Ni Zhong, Mingxin Gao, Junyan Liu, Zhimin Qi, Zili Liu, Naikang Rong, Minghui Zhang, Dongfang Li, Qiyue Zhang, Gongming Yang, Xinxin Zhang, Mingyue Zhang, Ning Ding, Yu-qi Ping, Zhao Yang, Peng Xiao, Ming Xia#, Xiao Yu#, Alatan Gaole#, Jin-Peng Sun#, and Fan Yang#. Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement. Molecular Cell. 2025 Apr 17;85(8):1658-1673.e7. Co-Corresponding Author，Second to Last，Citations:1，Accompanying commentary in the same issue of Molecular Cell.
Chunyou Mao, Ru-Jia Zhao, Ying-Jun Dong, Mingxin Gao, Li-Nan Chen, Chao Zhang, Peng Xiao, Jia Guo, Jiao Qin, Dan-Dan Shen, Su-Yu Ji, Shao-Kun Zang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Jin-Peng Sun#, and Yan Zhang#. Conformational transitions and activation of the adhesion receptor CD97. Molecular Cell. 2024 Feb 1;84(3):570-583.e7. Co-Corresponding Author，Second to Last,Citations:5.
Zhao Yang, Shu-Hua Zhou, Qi-Yue Zhang, Zhi-Chen Song, Wen-Wen Liu, Yu Sun, Ming-Wei Wang, Xiao-Long Fu, Kong-Kai Zhu, Ying Guan, Jie-Yu Qi, Xiao-Hui Wang, Yu-Nan Sun, Yan Lu, Yu-Qi Ping, Yue-Tong Xi, Zhen-Xiao Teng, Lei Xu, Peng Xiao, Zhi-Gang Xu, Wei Xiong, Wei Qin, Wei Yang#, Fan Yi#, Ren-Jie Chai#, Xiao Yu#, Jin-Peng Sun#. A force-sensitive adhesion GPCR is required for equilibrioception. Cell Research. 2025 Apr;35(4):243-264. Senior Corresponding Author，Citations:2，Featured commentary in the same issue of Cell Research.
Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, Jingang Zheng, Chenfeng Mao, Zhiqing Li, Zhixin Liu, Bing Yu, Tuoyi Li, Meili Wang, Chanjuan Xu, Yiwei Zhou, Guizhen Zhao, Yiting Jia, Wei Guo, Xin Jia, Tao Zhang, Li Li, Ziyi Liu, Shengchao Guo, Mingliang Ma, Heng Zhang, Bo Liu, Junbao Du, Wengong Wang, Chaoshu Tang, Pei Gao, Qingbo Xu, Xian Wang, Jianfeng Liu, Jinpeng Sun# and Wei Kong#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Research. 2021 Jul;31(7):773-790. Co-Corresponding Author，Second to Last，Citations: 43.
Hong-Mei Wang, Yun-Fei Xu, Shang-Lei Ning, Du-Xiao Yang, Yi Li, Yu-Jie Du, Fan Yang, Ya Zhang, Nan Liang, Wei Yao, Ling-Li Zhang, Li-Chuan Gu, Cheng-Jiang Gao, Qi Pang, Yu-Xin Chen, Kun-Hong Xiao, Rong Ma, Xiao Yu#, Jin-Peng Sun#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. 2014 Sep;24(9):1067-90. Senior Corresponding Author，Citations: 75.
Yufei Chen, Chenfeng Mao, Rui Gu, Rujia Zhao, Weihao Li, Zihan Ma, Yiting Jia, Fang Yu, Jian Luo, Yi Fu, Jinpeng Sun#, Wei Kong#. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circulation Research. 2022 Dec 2;131(12):1037-1054. Co-Corresponding Author，Second to Last.
Qingqing Chu, Yujia Li, Jichao Wu, Yanjiao Gao, Xiangyun Guo, Jing Li, Hang Lv, Min Liu, Wei Tang, Peng Zhan, Tao Zhang, Huili Hu, Hong Liu, Jinpeng Sun#, Xiaojie Wang#, Fan Yi#. Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension. Circulation Research. 2024 Sep 13;135(7):708-721. Co-Corresponding Author，Third to Last,Citations: 42.
Lin-Qi Zhang, Chang-Xiao Che, Ya-Qin Du, Lu-lu Han, Jia-le Wang, Chen-Yu Zhang, Shen-Ming Huang, Zhong-Yuan Zheng, Qing-Tao He, Zhao Yang, Long Zhang, Nan Chen, Fan Yang, Ying-Li Jia, Shi-Min Zhao, De-min Zhou, Chu Wang, Xian Wang, Jin-Peng Sun#, Lu Tie#. N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation. Blood. 2025 May 15;145(20):2374-2389. Co-Corresponding Author，Second to Last.
Jun-Hong Dong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, Dong-Fang He, Qiao-Xia Hu, Dao-Lai Zhang, Shang-Lei Ning, Chun-Hua Liu, Chuan Wang, Yue Wang, Xiang-Yao Li, Fan Yi, Amy Lin, Alem W. Kahsai, Thomas Joseph Cahill Ⅲ, Zhe-Yu Chen, Xiao Yu, and Jin-Peng Sun#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1-regulated lactate metabolism. Biological Psychiatry. 2017 Apr 15;81(8):654-670.Sole Corresponding Author, Citations: 42, Cover Article.
Wentao An, Hui Lin, Lijuan Ma, Chao Zhang, Yuan Zheng, Qiuxia Cheng, Chuanshun Ma, Xiang Wu, Zihao Zhang, Yani Zhong, Menghui Wang, Dongfang He, Zhao Yang, Lutao Du, Shiqing Feng, Chuanxin Wang, Fan Yang, Peng Xiao#, Pengju Zhang#, Xiao Yu#, and Jin-Peng Sun#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proceedings of the National Academy of Sciences of the United States of America. 2022 Apr 12;119(15):e2117004119. Senior Corresponding Author，Citations: 29.
Shen-Ming Huang, Meng-Yao Xiong, Lei Liu, Jianqiang Mu, Ming-Wei Wang, Ying-Li Jia, Kui Cai, Lu Tie, Chao Zhang, Sheng Cao, Xin Wen, Jia-Le Wang, Sheng-Chao Guo, Yu Li, Chang-Xiu Qu, Qing-Tao He, Bo-Yang Cai, Chenyang Xue, Shiyi Gan, Yihe Xie, Xin Cong, Zhao Yang, Wei Kong, Shuo Li, Zijian Li, Peng Xiao, Fan Yang, Xiao Yu, You-Fei Guan, Xiaoyan Zhang#, Zhongmin Liu#, Bao-Xue Yang#, Yang Du#, Jin-Peng Sun#. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proceedings of the National Academy of Sciences of the United States of America. 2023 Jul 25;120(30):e2216329120. Senior Corresponding Author，Citations: 9.
Ming-Wei Wang, Zhao Yang, Xu Chen, Shu-Hua Zhou, Ge-Lin Huang, Jian-Ning Sun, Hui Jiang, Wen-Ming Xu#, Hao-Cheng Lin#, Xiao Yu#, Jin-Peng Sun#. Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov 9;118(45):e2107363118. Senior Corresponding Author， Citations: 11.
Changxiu Qu, Ji Young Park, Min Woo Yun, Qing-tao He, Fan Yang, Kiae Kim, Donghee Ham, Rui-rui Li, T. M. Iverson, Vsevolod V. Gurevich, Jin-Peng Sun#, and Ka Young Chung#. Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 14;118(37):e2026491118. Co-Corresponding Author，Second to Last, Citations: 36.
Lijuan Ma, Fan Yang, Xiang Wu, Chunyou Mao, Lulu Guo, Tianshu Miao, Shao-Kun Zang, Xiaoyu Jiang, Dan-Dan Shen, Tianhui Wei, Hengxing Zhou, Qin Wei, Shiyang Li, Qiang Shu, Shiqing Feng, Changtao Jiang, Bo Chu, Lutao Du#, Jin-Peng Sun#, Xiao Yu#, Yan Zhang#, and Pengju Zhang#. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proceedings of the National Academy of Sciences of the United States of America. 2022 Jul 19;119(29):e2117054119. Co-Corresponding Author, Fourth to Last. Citations: 17.
Contact Information
Jinpeng Sun Department of Physiology and Pathophysiology, Peking University Health Science Center
Email: sunjinpeng@bjmu.edu.cn or sunjinpengsdu@126.com
Tel: 010-82805639
Our laboratory aims to cultivate future scientists and research leaders. We welcome students interested in biological research to apply, and we also welcome graduate students and undergraduates from medical and biological sciences to join our group for study and exchange!