Ming Zheng, M.D., Ph.D. Dr. Zheng obtained her M.D. in 1993 from Xi'an Medical University and her Ph.D. in 2001 from Peking University. Currently Dr. Zheng’s research interests mainly focus on the changes and mechanisms of mitochondrial dynamics, mitochondrial networks, mitochondria-sarcoplasmic reticulum crosstalk and mitophagy during cardiovascular diseases and exercises. Dr. Zheng is now the Principal Investigator of several national grants.
Email: zhengm@bjmu.edu.cn

Co-PI of the Laboratory

Limei Liu, Ph.D.

Education and professional experience:

s 1995.9-2000.7 Mudanjiang Medical College, Degree awarded (2000): Bachelor of Medicine

s 2000.9-2003.7 Department of Pathology and Pathophysiology, Harbin Medical University, China, Degree awarded (2003): Master of Philosophy

s 2009.1-2011.8 Department of Physiology, Chinese University of Hong Kong, China, Degree awarded (2011): Doctor of Philosophy

s 2003.8-2005.7 Teaching Assistant, Dept. of Physiology and Pathophysiology, Peking University Health Science Center

s 2005.8-2016.7 Lecturer, Dept. of Physiology and Pathophysiology, Peking University Health Science Center

s 2016.8- Associate professor, Dept. of Physiology and Pathophysiology, Peking University Health Science Center

Research directions: To explore the mechanism of endothelial dysfunction; to examine drug intervention and therapeutic targets for regulating endothelial function.

Email: limei_liu@163.com

Research Directions

1. The network and quality control of cardiac mitochondria and the cross talk and molecular linkers of cardiac mitochondria with sarcoplasmic reticulum;

2. The regulation of skeletal muscle homeostasis during exercises;

3. The regulation of endothelial function.

   
   

Publications

1. Weng L, Ye J, Yang F, Jia S, Leng M, Jia B, Xu C, Zhao Y, Liu R, Xiong Y, Zhou Y, Zhao J, Zheng M*. TGF-b1/SMAD3 Regulates Programmed Cell Death 5 That Suppresses Cardiac Fibrosis Post-Myocardial Infarction by Inhibiting HDAC3. Circ Res. 2023 Jul 21; 133:237-251

2. Liu RX, Xu CL, Zhang WL, Cao YP, Ye JJ, Li B, Jia S, Weng L, Liu YY, Liu L, Zheng M*. FUNDC1-mediated mitophagy and HIF1a activation drives pulmonary hypertension during hypoxia. Cell Death & Disease. 2022; 13:634

3. Xu C, Cao Y, Liu R, Liu L, Zhang W, Fang X, Jia S, Ye J, Liu Y, Weng L, Qiao X, Li B, Zheng M*. Mitophagy-regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction. J Cell Mol Med. 2022;26:1315–1326

4. Cao YP, Xu CL, Ye YY, He QH, Zhang XZ, Jia S, Qiao X, Zhang CL, Liu RX, Weng L, Liu YY, Liu L, Zheng M*. Miro2 regulates inter-mitochondrial communication in the heart and protects against TAC-induced cardiac dysfunction. Circ Res. 2019 Sep 27; 125(8):728-743

5. Ye J, Zheng Q, Jia S, Qiao X, Cao Y, Xu C, Weng L, Zhao L, Chen Y, Liu J, Wang T, Cheng H, Zheng M*. Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of SERCA2a Protein. Hypertension. 2018; 72(4): 889–901

6. Weng L, Jia S, Xu C, Ye J, Cao Y, Liu Y, Zheng M*. Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61α in mouse hearts. Cell Death & Disease. 2018, 9(6): 612.

7. Jia S, Qiao X, Ye J, Fang X, Xu C, Cao Y, Zheng M*. Nogo-C Regulates Cardiomyocyte Apoptosis during Mouse Myocardial Infarction. Cell Death & Disease. 2016,7(10): e2432

8. Huang X, Sun L, Ji S, Zhao T, Zhang W, Xu J, Zhang J, Wang Y, Wang X, Franzini-Amstrong C*, Zheng M*, Cheng P. Kissing and nanotunneling mediate intermitochondrial communication in the heart. Proc Natl Acad Sci U.S.A. 2013; 110(8):2846-2851.

9. Hao H, Liu L*, Pan C, Wang C, Gao Y Fan J Han J*, Rhynchophylline ameliorates endothelial dysfunction via Src-PI3K/Akt-eNOS cascade in the renal arteries of spontaneous hypertensive rats, Front Physiol. 15 November 2017.

10. Liu L*, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KS, Chen ZY, Ng CF, Yao X, Huang Y*. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 2012; 60(3):833-841

Grants

1. Mechanisms of EMC6/ERAD in regulating SR homeostasis during cardiac hypertrophy. National Natural Science Foundation of China (Ming Zheng)

2. Exercise on development and homeostasis. National Key Research and Development Program of China (Ming Zheng)

3. Mitochondria-sarcoplasmic reticulum interactions in cardiac mypertrophy. National Natural Science Foundation of China (Ming Zheng)

4. The role of PDCD5 in the pathogenesis of cardiac hypertrophy. National Natural Science Foundation of China (Ming Zheng)

5. The function and mechanism of PTPIP51 in cardiac ischemia/reperfusion injury. National Natural Science Foundation of China (Ming Zheng)

6. Mechanisms of cardiac inter-mitochondrial communication and the pathophysiological relevance. National Natural Science Foundation of China (Ming Zheng)

7. Mechanisms and intervention strategy of mitochondria dysfunction in early heart failure. National Key Basic Research Program of China (Ming Zheng)

8. The Role of uncoupling protein 2 in the improved endothelial function by epoxyeicosatrienoic acids in hypertensive renal arteries. National Nature Science Foundation of China (Limei Liu)

9. Glucagon-like peptide-1 improves vascular endothelial function by up-regulating its receptor in high fat diet-induced obese mice. National Nature Science Foundation of China (Limei Liu)

10. Mitochondrial mechanism of glucagon-like peptide-1 on the improvement of vascular endothelial function in hypertension. National Nature Science Foundation of China (Limei Liu)

11. The function and mechanism of Nogo-C in regulation of cardiomyocyte sarcoplasmic reticulum calcium homeostasis. National Nature Science Foundation of China (Shi Jia)

Textbooks

1. 《病理生理学》英文版第二版，人民卫生出版社，2020年，参编第十五章“心力衰竭”。（刘利梅）

2.《病理生理学》英文版第二版，科学出版社，2021年，参编第十六章“心力衰竭”。（刘利梅）

Lab members