Introduction

Professor Kai Wang is an Assistant Professor in the Department of Physiology and Pathophysiology, Peking University. He also serves as a PI in the State Key Laboratory of Vascular Homeostasis and Remodeling. He earned his Ph.D degree at Peking University and finished his postdoctoral training in Harvard Medical School/Boston Children’s Hospital and Cornell University from 2016 to 2021. His lab focuses on the interdisciplinary research on the stem cells and vascular organoid. He now serves as Associate Editor in the journal of Microvascular Research and Cell Organoid while sitting in the editorial board of Cell Transplantation. He has published 18 peer-reviewed papers in highly impacted scientific journals including Sci Adv, Adv Sci, Adv Mat, Biomaterials and et al. He also serves as ad hoc reviewer for journals including Sci Adv, ACS Nano, Angiogenesis and et al.

Research of Focus

His research interest has focused on developing stem cell derived vascular organoids for disease modeling and cell therapy.

1) Exploit key transcription factors to optimize the mass production of functional organoids for cell therapy.

2) Patient derived iPSCs for modeling diseases including atherosclerosis, Marfan Syndrome and mitochondrial diabetes.

3) Novel biomaterials including hydrogel and 3D scaffold for cell assembling, packaging and delivery.

Selected Publications

1. Xuanyu Liu#, Qingyi Zeng#, Hang Yang, Wenke Li, Qianlong Chen, Kunlun Yin, Zihang Pan, Kai Wang*, Mingyao Luo*, Chang Shu*, Zhou Zhou*. Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root. Advanced Science, 2024

2. Yi Wang, Kai Wang*, Xi Wang, Ying Luo*, Haifeng Chen*. Hydrogel-composited laminate for islet immune-isolation to treat type 1 diabetes. ACS Appl. Mater. Interfaces, 2024, In press

3. Yun Zhao#, Xi Wang#, Kai Wang*. Transcription factor-mediated programming of stem cell fate. Trends in Cell Biology. 2023, 33(8):621-624

4. Yi Wang, Kai Wang*, Ying Luo*, Haifeng Chen*. Hydrogel-Bondable Asymmetric Planar Membranes with Hierarchical Pore Structures for Cell Scaffolding and Encapsulation. ACS Biomaterials Science & Engineering. 2023, 9(3): 1706-1719

5. Xiaojing Ma#, Hongfei Li#, Shuntian Zhu, Zixuan Hong, Weijing Kong, Qihang Yuan, Runlong Wu, Zihang Pan, Jing Zhang, Yahong Chen, Xi Wang*, Kai Wang*. Angiorganoid: vitalizing the organoid with blood vessels. Vascular Biology. 2022, 4 (1):R44-R57.

6. Kai Wang, Ruei-Zeng Lin, Alex H. Ng, Xuechong Hong, Chin Nien Lee, Joseph Neumeyer, Gang Wang, Xi Wang, Minglin Ma, William T. Pu, George M. Church, Juan M. Melero-Martin*, Robust Differentiation of Human Pluripotent Stem Cells into Endothelial Cells via Temporal Activation of ETV2 with Modified mRNA. Science Advances 2020; 6(30): eaba7606.

7. Kai Wang, Xi Wang, Chengsheng Han, Wenda Hou, Jinyang Wang, Liangyi Chen, Ying Luo*, From Micro to Macro: The Hierarchical Design in a Micropatterned Scaffold for Cell Assembling and Transplantation. Advanced Materials 2017, 29 (2): 1604600.

8. Xi Wang#, Kai Wang#, Wei Zhang#, Ying Luo*, A Bilaminated Decellularized Scaffold for Islet Transplantation: Structure, Properties and Functions in Diabetic Mice. Biomaterials 2017,138: 80-90. (# equal contribution).

9. Kai Wang, Wenda Hou, Xi Wang, Chengsheng Han, Ivan Vuletic, Ni Su, Wenxi Zhang, Qiushi Ren, Liangyi Chen, Ying Luo*, Investigating Nano Topography-driven Material Properties: A Study on Biocompatibility and Immunoisolation Function of a Nanofibrous Membrane. Biomaterials 2016, 102: 249-258.

10. Kai Wang, Linyang Yu, Liyang Jiang, Haibin Wang, Changyong Wang, Ying Luo*, The Paracrine Effects of Adipose-derived Stem Cells on Neovascularization and Biocompatibility of a Macroencapsulation Device. Acta Biomaterialia 2015, 15: 65-76.

Contact information

Kai Wang

Assistant Professor

Department of Physiology and Pathophysiology

Peking University Health Science Center

Xueyuan Road 38, Haidian District

Tel: 861082801477

Email: kai.wang88@@pku.edu.cn (delete one @)

Lab website：https://www.x-mol.com/groups/kai_wang_pku

Google Scholar : https://scholar.google.com/citations?hl=en&user=51QhyuYAAAAJ&view_op=list_works&sortby=pubdate

Twitter：@KaiWang_PKU