YAO Weijuan, Associate Professor. 

Dr. Yao received her Ph.D. degree from Peking University Health Science Center in June, 2002, and did her postdoc research in Department of Bioengineering at University of California, San Diego. She returned to Peking University Health Science Center and worked in Department of Physiology and Pathophysiology in Sep., 2008. Dr. The main research projects and findings include: (1) Mechanical regulatory mechanisms of vascular homeostasis and remodeling under disease conditions: Identified that endothelial inflammation and monocyte adhesion induced by follicle-stimulating hormone (FSH) contribute to the development and progression of atherosclerosis associated with androgen deprivation therapy in prostate cancer patients; revealed the role of the APEX1-STAT3 signaling axis in force-induced endothelial regeneration. (2) Mechanical regulatory mechanisms of immune cell-mediated inflammatory responses: Demonstrated that DNA methyltransferase DNMT1 regulates macrophage motility and wound healing by influencing cholesterol aggregation. (3) Regulation of cytoskeletal proteins in receptor endocytosis and immune responses: Discovered that the cytoskeletal protein Tmod1 modulates Toll-like receptor 4 endocytosis and macrophage inflammatory responses by affecting cell membrane tension; regulates immune function by influencing the maturation process and mechanical properties of dendritic cells; and controls macrophage mechanoresponses on substrates of varying stiffness as well as the progression of atherosclerosis. Dr. Yao has published over 40 SCI papers in journals such as ATVB, Frontiers in Immunology, Cell Mol Life Sci, and NPJ Regen Med, etc. She received funding from National Natural Science Foundation of China and Natural Science Foundation of Beijing. Dr. Yao also serves as a committee member for Hemorheology Council of Microcirculation Society of China.

Contact Information

Weijuan Yao

Department of Physiology and Pathophysiology

Peking University Health Science Center

38 Xueyuan Road, Haidian District

Office: Physiology Building, Room 312

Tel: +86-10-82802419, 13717802916

Email: weijuanyao@bjmu.edu.cn