Ruo-Lan Xiang, PhD
Associate Professor, Master’s Supervisor

  Dr. Xiang obtained her PhD from Peking Union Medical College in June 2006. In September 2006, she joined the faculty of the Department of Physiology and Pathophysiology at Peking University Health Science Center. Dr. Xiang has published over 70 SCI-indexed papers in internationally recognized journals including European Heart Journal, Cell Research, Aging Cell, Oral Diseases, Cells, and Life Sciences.

Research interest：

· Mechanisms of diabetes and its complications

· Mechanisms of salivary gland diseases

Selected Publications：

1. Yang YL, Xiang ZJ, Yang JH, Wang WJ, Xu ZC, Xiang RL. Association of β-blocker use with survival and pulmonary function in patients with chronic obstructive pulmonary and cardiovascular disease: a systematic review and meta-analysis. European Heart Journal. 2020, 41: 4415-4422.

2. Chen Z, Mao QY, Zhang JY, Wu YX, Shan XF, Geng Y, Fan JY, Cai ZG*, Xiang RL*. Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice. Aging Cell. 2025, 24(5): e14470.

3. Mao QY, Huang Y, Chen Z, Shan XF, Xie S, Wu LL, Xiang RL*, Cai ZG*. Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis. Cells. 2025, 14(17): 1366.

4. Zou YP, Shan XF, Qiu JX, Geng Y, Xie S, Xiang RL*, Cai ZG*. Systematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carcinoma. Scientific Reports. 2025, 15(1): 1573.

5. Zou YP, Shan XF, Qiu JX, Wang LN, Xiang RL*, Cai ZG*. Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and IκB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing. Biomedicine & Pharmacotherapy. 2024, 174: 116468.

6. Mao QY, Chen Z, Xie S, Xiang RL*, Cai ZG*. F-actin/DRP1 axis-mediated mitochondrial fission promotes mitophagy in diabetic submandibular glands. Oral Diseases. 2024, 00: 1-16.

7. Huang Y, Liu HM, Mao QY, Wu LL, Xiang RL*, Yu GY*. Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse. BMC Genomics. 2024, 25: 450.

8. Huang Y, Liu HM, Mao QY, Cong X, Zhang Y, Lee SW, Park K, Wu LL, Xiang RL*, Yu GY*. High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway. Cells. 2021, 10: 3230.

9. Huang Y, Liu HM, Wu LL, Yu GY, Xiang RL. Long non-coding RNA and mRNA profile analysis in the parotid gland of mouse with type 2 diabetes. Life Sciences. 2021, 268: 119009.

10. Mao QY, Xie S, Wu LL, Xiang RL*, Cai ZG*. MicroRNA-mRNA expression profiles and functional network after injection of botulinum toxin type A into submandibular glands. Toxicon. 2021,199:31-40.

Fundings

Dr. Xiang has presided several research projects supported by the National Natural Science Foundation of China and the Beijing Natural Science Foundation.

Contact information

Office: Physiology Building
Email: xiangrl@bjmu.edu.cn